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In 2018, the FDA granted approval to cannabidiol (CBD; Epidiolex) for the treatment of rare forms of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome, and while the addition was a welcomed one, this did not mark the complete understanding of the therapyโ€™s use. Although CBD and other medications continue to be studied in some instances post-approval and often for other conditions, the need for subgroup analysesโ€”especially in epilepsyโ€”is paramount. As Kelly Knupp, MD, pediatric neurologist and epilepsy specialist, Childrenโ€™s Hospital Colorado, pointed out in a conversation with NeurologyLive, when it comes to CBD, physicians still do not completely understand why specific subgroups of patients respond to CBD and others do not. โ€œI think it would be worthwhile to look at that and try to figure that out,โ€ Knupp said. The data from the clinical trials are compelling, she noted, but itโ€™s important to remember that patients, while achieving reductions, have not been achieving seizure freedom. At the 2019 International Epilepsy Congress, June 22-26, in Bangkok, Thailand, she spoke about the use of cannabinoids in epilepsy and where they may play a role in other epilepsies.

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