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New evidence brings more good news about the unanticipated effects of the GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt -- TRANSCRIPT -- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. It’s quite a thing that we live in an era with the biggest blockbuster weight-loss drugs in history, and I can look at you straight-faced and say, yeah, but honestly that’s not the most interesting thing about the GLP-1 receptor agonists such as Ozempic. Beyond their clear utility in weight loss, we have good data that demonstrate the drugs lead to improvements in rates of heart disease, liver disease, and even all-cause mortality, and intriguing reports of strange off-target effects: a reduction in gambling, drinking, drug use, smoking, and compulsive shopping. It’s honestly hard to find an organ system or self-destructive behavior that GLP-1 drugs don’t seem to improve somehow. It’s almost strange. It’s as if the statins came out and everyone was excited about the cholesterol going down, and then we discovered that they reversed hair loss or took three strokes off your golf game. How does one drug do so many things? I think the behavioral changes are the clue. The fact that people may drink or smoke less on these drugs should tell you that something is happening in their brains. And if these drugs are acting on the brain, you might well wonder if they can reduce the risk for brain disease — dementia. And, at least according to a new study, the answer appears to be yes. As the GLP-1 drugs started getting more and more popular, I decided to perform some due diligence and refresh what I had learned in med school about this thing called “glucagon-like peptide.” These drugs bind to the same receptor that GLP does, primarily to cause the pancreas to release more insulin when blood sugar is high. But we have plenty of drugs that stimulate insulin release. And they don’t seem to have all these other weird effects. So, what’s going on? When a drug acts on a specific receptor, it is worth seeing what cells in the body have that receptor, and this is a pretty interesting figure that shows that. You see high expression in the pancreas — no surprise. But next is expression in the heart muscle — interesting, considering these drugs have been shown to reduce the risk for heart disease. Then the salivary glands, and then… the cerebral cortex. The brain. And not just any part of the brain, the thinking part of the brain. A lot happens when these drugs bind to a receptor on a cell. But the brain is a mysterious and important organ. In contrast, the heart is relatively simple, and there are multiple randomized trials that show that GLP-1 drugs, as well as some other drugs for diabetes, such as the SGLT2 inhibitors, pioglitazone, and metformin, reduce the risk for cardiovascular disease in people with diabetes. So, it makes sense to ask whether these drugs would do the same for brain disease. Enter this study, "Cardioprotective Glucose-Lowering Agents and Dementia Risk," from Catriona Reddin and colleagues in JAMA Neurology. It’s an impressive bit of work combining data from 23 different randomized trials of these drugs including more than 150,000 individual people, to determine whether they reduce the risk for dementia. This is the best evidence we have to date for a neuroprotective effect of GLP-1 inhibitors. And this is the only type of study that could give us this evidence. The reason you need to combine so much data to detect a signal is that, to date, no randomized trials of GLP-1 drugs have been designed with dementia as a primary outcome. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt

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A bold move was made by Keto Tone, a popular weight loss supplement company when they entered the Shark Tank to pitch their product. This has caused a lot of buzz in the health and fitness community with many wondering if this gamble paid off for Keto Tone. In this article, we will look at Keto Tone’s venture into Shark Tank and assess if it was worth it in terms of exposure, funding, and overall success.

The Pitch

When they entered Shark Tank the founders of Keto Tone knew that they had to make an impact on the investors. Consequently, they confidently presented their product through highlighting its unique selling points and benefits. The success stories and clinical studies told by the founders were interesting but there were also hard questions asked about the ingredients of their product, market competition as well as scalability from Sharks.

Even though there was skepticism as well as pushback from some Sharks, founders of Keto Tone stood firm and passionately defended their brand. They pointed out that the customers’ positive feedbacks and growing demand for keto products in the market are enough proof that they are doing something right. All together, excitement hung in the air as well as high stakes characterized the pitch while presenting why investment should be done towards Keto Tone.

The Deal

After much debate and haggling over specific terms, one of the Sharks finally agreed to partner with them. It was a win-win situation for both parties whereby an investor received a stake in a company while providing funding plus expertise to it. Through this partnership, Keto Tone was able to take vital steps towards accelerating its growth rate while broadening its customer base.

This offer meant everything for Keto Tone since it proved that they had got everything and more than what an investor wants to see for them to invest in business or idea he does not know anything about; hence validating its vision plus business model. The idea that there is a Shark who believed in their product by deciding whether or not swim is another milestone that they were thrilled to have reached. This cooperation was a threshold moment that would shape the future of Keto Tone.

The Aftermath

Keto Tone’s appearance on Shark Tank led to a rise in demand and sales. Their show helped raise the awareness levels of their brand and also boosted its credibility. Partnership with the Shark investor opened up new opportunities for collaboration that otherwise would not have been possible.

Keto Tone’s journey on Shark Tank was indeed a “calculated risk” but one that paid off in terms of brand visibility and growth. The founders’ decision to take a shot at the show turned out to be strategic as it catalyzed their business. As they enhance their product line reaching more clients, this moment is of paramount importance in the success story of Keto Tone.

Conclusion

In conclusion, it can be said without fear of contradiction, that Keto Tone’s venture into Shark Tank was totally worth it. The company has immensely benefited from exposure, funding, and partnerships initiated through this program. By putting their brand upfront on national stage; Keto tone attracted new investors who brought along new consumers making it become an industry connected entity which is helping them survive in a competitive environment.

With its continuing innovation and broadening them in product range, Keto Tone will make the effects of their appearance on Shark Tank resonate for a long time to come in the business world. This brave action did not only earn them immediate gains but also made them notable players within health and wellness industry. For Keto Tone, running this risk was worth the reward and it will be remembered as a turning point in their entrepreneurial journey that began with Shark Tank experience.

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