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Game-Changing GLP-1 Pills: Latest News, Breakthroughs, and Market Impact This week's episode of the Downsized News delves into the latest advancements and market dynamics surrounding GLP-1 medications for obesity and diabetes. Key stories include a new daily weight loss pill from Eli Lilly, Novo Nordisk's high-dose Semaglutide pill, and Pfizer's withdrawal from the GLP-1 pill race due to safety concerns. The episode also discusses the potential market value surpassing that of Apple's iPhone, breakthrough studies showing the efficacy of GLP-1s regardless of genetics, and their potential in treating dementia and Bardet-Biedl syndrome. Additionally, the changing consumption habits of GLP-1 users and their impact on the food industry are explored. Hosts Laraine and Christopher Durham share their personal weight loss journeys using GLP-1 medications and remind viewers to consult healthcare professionals before starting any new treatment. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: / @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Hosts' Weight Loss Journeys 01:06 Eli Lilly's Groundbreaking Weight Loss Pill 03:17 Novo Nordisk's High Dose Semaglutide Pill 05:41 Pfizer Exits the Oral GLP-1 Race 07:43 GLP-1 Market's Massive Potential 09:51 GLP-1s and Rare Genetic Disorders 11:32 GLP-1s' Effectiveness Regardless of Genetics 14:01 GLP-1s and Dementia Risk Reduction 15:25 GLP-1s Changing Eating Habits and the Food Industry 18:07 Conclusion and Sign-Off

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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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How To Take Ozempic Pen The weight loss drug, Ozempic contains Semaglutide and is given once weekly under the skin via injection and the dose can be increased at 4 weekly intervals. So with ozempic dosage regimen, 0.25mg once a week for 4 weeks, then from week 5, increased to 0.5mg and you can stay on this dose or it can be increased after every 4 weeks to a maximum dose of 2mg. Wegovy is taken as 0.25mg, 0.5mg,1 mg, 1.7mg, 2.4mg every 4 weeks #ozempic #weightloss