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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?

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What’s a calorie deficit? A calorie deficit means eating fewer calories than your body burns. In more technical terms, it’s the state in which your energy intake is lower than energy expended. How does it impact weight loss? A calorie deficit prompts your body to tap into stored energy reserves—primarily fat—to make up for the shortfall. This is what ultimately leads to weight loss. Eating too few calories can pose risks to physical and mental health. Severely restricting calories can eventually lead to nutrient deficiencies and side effects like weakened immunity, fatigue, brain fog, or trouble concentrating. Calories aren’t the only piece of the puzzle. The nutritional quality of your meals and snacks, exercise routine, sleep habits, hydration, and mindfulness are also important. Rather than being laser-focused on calorie intake, we recommend a holistic approach for sustainable, safe weight loss that incorporates these other key components. Visit our blog to learn more: https://www.forhers.com/blog/what-is-a-calorie-deficit The information provided here is NOT MEDICAL ADVICE and is for informational purposes only. Please contact your provider if you have any further questions regarding your condition or treatment.

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00:00 Intro Story 00:47 Intro 01:22 What is overweight and Obesity? 02:16 Burden of obesity 02:52 Diseases associated with Obesity 03:11 Difficulties of losing weight 04:18 How these weight loss medicines work? Semaglutide , Ozempic , Mounjaro 05:45 How long it will take to lose weight? 06:35 Who are all benefit from these weight loss medicines? 7:36 Other health benefits of these weight loss medications 08:20 Side effects of weight loss medications 09:21 How long we should take weight loss medications? 10:18 Do I gain weight after stopping these weight loss medications? 10:44 Cost of these medications in India 12:10 Quick tips 13:12 Outro Join me as I dive into the world of Ozempic and Mounjaro to see if they really live up to the hype for weight loss! Ozempic and Mounjaro are two medications that have been gaining popularity in the weight loss market, and many people are wondering if they can really help them achieve their weight loss goals. Obesity and weight management are challenges that many individuals face, and it's an issue that affects not just physical health, but also mental wellbeing. Millions of people struggle with excess weight, and it's a major risk factor for chronic diseases like diabetes, heart disease, and certain types of cancer. The emotional toll of being overweight can be just as damaging as the physical, leading to low self-esteem and a lack of confidence. Finding effective solutions to weight loss is crucial, as it can greatly improve overall health and quality of life. Many people have tried various diets and exercise programs, but they often end up feeling frustrated and disappointed with the results. The mechanisms behind Ozempic and Mounjaro are quite complex, but essentially they work by mimicking hormones in the body that help regulate blood sugar levels and appetite. Ozempic, also known as semaglutide, has been shown in clinical studies to be highly effective in promoting weight loss, with some participants losing up to 10% of their body weight. Mounjaro, or tirzepatide, has also demonstrated impressive results, with significant weight loss and improvements in blood sugar control. As with any medication, there are potential side effects to consider, such as nausea, vomiting, and increased risk of pancreatitis. Research on Ozempic and Mounjaro has been extensive, with numerous clinical trials demonstrating their safety and efficacy. The results are quite impressive, with many participants achieving significant weight loss and improvements in their overall health. For example, one study found that participants taking Ozempic lost an average of 15% of their body weight over a period of 68 weeks. Another study on Mounjaro showed that participants achieved an average weight loss of 20% over a period of 72 weeks. These medications have the potential to revolutionize the way we approach weight loss, offering a new hope for those who have struggled with traditional methods. Many people have already started using Ozempic and Mounjaro, and the results are nothing short of amazing. Some have reported losing large amounts of weight in a short period of time, while others have seen significant improvements in their blood sugar control and overall health. The success stories are numerous, and they're a testament to the potential of these medications to transform lives. With the right mindset and support, people can achieve their weight loss goals and improve their overall wellbeing. The statistics are also impressive, with some studies showing that up to 80% of participants achieve significant weight loss with Ozempic or Mounjaro. In conclusion, Ozempic and Mounjaro are two medications that have the potential to revolutionize the way we approach weight loss. They offer a new hope for those who have struggled with traditional methods, and the results are nothing short of amazing. With their impressive mechanisms, clinical studies, and success stories, it's clear that these medications are worth considering for those looking to achieve their weight loss goals. If you've had any experience with Ozempic or Mounjaro, please share your story in the comments below. And if you're interested in learning more about weight loss and health topics, be sure to check out my other videos for more information and tips. #appetitesuppressant, #tirzepatide, #GLP-1agonists, #weightloss, #obesitytreatment, #wegovy, #weightlossjourney,#ozempic, #ozempicsideeffects, #mounjaro, #fitness, #diet, #mounjaroweightloss, #insulinresistance, #obesity, #pharmaceuticalweightloss, #bodytransformation, #semaglutide #weightlossdrugs,#obesitytreatment,#healthtips, #glucagonlikepeptide, #ozempic #mounjaro #semaglutideforweightloss #weightlossdrugs

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