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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].
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Goxtra Keto is designed to help your body enter and maintain a state of ketosis, where it burns fat for fuel instead of carbohydrates. This is the key to achieving weight loss and improved energy levels on the keto diet. The powerful ingredients in Goxtra Keto work synergistically to support ketosis and help you see results faster than with diet and exercise alone.
One of the key ingredients in Goxtra Keto is beta-hydroxybutyrate (BHB) ketones, which are exogenous ketones that can help your body get into ketosis more quickly. By providing your body with a source of ketones, Goxtra Keto makes it easier for you to stay in ketosis and burn fat for energy.
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Using Goxtra Keto is simple and straightforward. Just take two capsules daily with a glass of water, preferably before a meal. For best results, continue taking Goxtra Keto consistently for at least 30 days while following a ketogenic diet and staying hydrated.
It’s important to remember that Goxtra Keto is a supplement and should be used in conjunction with a healthy diet and regular exercise. While Goxtra Keto can help support your keto journey, it’s not a magic solution and won’t work if you’re not following a keto-friendly lifestyle. To make the most of Goxtra Keto, be sure to eat a balanced diet high in healthy fats, moderate in protein, and low in carbohydrates.
If you have any underlying health conditions or are taking medication, it’s always a good idea to consult with your healthcare provider before starting any new supplement, including Goxtra Keto. They can help determine if Goxtra Keto is right for you and ensure that it doesn’t interfere with any other treatments you may be undergoing.
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Yes, Goxtra Keto is made with natural ingredients and is generally safe for most adults to use. However, if you have any underlying health conditions or are pregnant or nursing, it’s best to consult with your healthcare provider before starting Goxtra Keto.
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Results may vary, but many users report seeing and feeling results within a few weeks of starting Goxtra Keto. Consistency is key, so be sure to take Goxtra Keto as directed and follow a healthy keto diet to maximize your results.
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Goxtra Keto is designed to support the ketogenic diet, so it works best when used in conjunction with a low-carb, high-fat diet. While you may still see some benefits from taking Goxtra Keto without following a keto diet, you’ll likely see better results if you’re in ketosis.
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5. Where can I buy Goxtra Keto?
You can purchase Goxtra Keto directly from the official website. Be sure to only buy from reputable sources to ensure you’re getting a genuine product and not a counterfeit or ineffective supplement.
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