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FULL EPISODE: https://www.youtube.com/watch?v=Thq6XOJIlFw Subscribe to our channel: https://www.youtube.com/@optispan Recent articles from outlets such as the BBC and CNN reported that GLP-1 agonists such as Ozempic, a drug used for the treatment of type 2 diabetes and obesity, may help lower risk and death rates from several diseases including COVID-19 and heart failure. Matt and Nick discuss mechanisms by which GLP-1 agonists might slow the biological aging process, the connection between health and biological age, and the potential for future, more effective versions of these drugs. They also touch on the importance of diet quality, protein intake, resistance training, and regular bloodwork and hormone profiling to understand the effects of GLP-1 agonists on the body and to mitigate potential side effects such as muscle and bone loss. GLP-1 agonists are medications that mimic the action of a hormone called glucagon-like peptide-1 (GLP-1), which is naturally produced in the gut, to manage type 2 diabetes. They regulate blood sugar levels by stimulating insulin release when blood sugar levels are high, slowing down digestion, and reducing the liver’s production of glucose. In recent years, GLP-1 agonists have gained attention for their role in weight management. By affecting appetite control centers in the brain, they help people feel fuller for longer, leading to reduced food intake and weight loss. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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Are you considering trying semaglutide for weight loss but want to hear from real patients about their experiences and results? Look no further! In this article, we will discuss semaglutide weight loss reviews and what patients are saying about their journey with this medication. Semaglutide has been gaining popularity in the weight loss community for its ability to help individuals shed excess pounds and improve their overall health. Let’s delve into the feedback from those who have tried semaglutide and see what they have to say.
Positive Results
Many patients who have tried semaglutide for weight loss report positive results. They have experienced significant reductions in weight, improved blood sugar levels, and even lower cholesterol levels. Some individuals have noted that they feel more energetic and have increased motivation to lead a healthy lifestyle. Overall, the feedback from those who have seen positive results with semaglutide is encouraging and inspiring.
One patient, Sarah, shared her experience with semaglutide, stating, “I have struggled with my weight for years, trying various diets and exercise routines with little success. Since starting semaglutide, I have lost 20 pounds in just two months! I feel amazing and have more confidence than ever before.”
Another patient, John, also had a positive experience with semaglutide. He shared, “I was skeptical at first, but after just a few weeks on semaglutide, I noticed a significant decrease in my appetite and cravings. I have lost 15 pounds so far, and my doctor is thrilled with my progress.”
Challenges and Side Effects
While many patients have seen positive results with semaglutide, some have faced challenges and experienced side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. Some individuals have also reported feeling tired or weak while on the medication. It is essential to consult with a healthcare provider before starting semaglutide to discuss potential side effects and how to manage them.
One patient, Alex, shared his struggles with side effects from semaglutide, stating, “I experienced severe nausea and vomiting when I first started taking semaglutide. It was challenging to stick with the medication, but with the help of my doctor, we adjusted the dosage, and I was able to manage the side effects better.”
Despite facing challenges, many patients have found ways to overcome them and continue on their weight loss journey with semaglutide. It is essential to listen to your body, communicate with your healthcare provider, and make any necessary adjustments to ensure a positive experience with the medication.

Long-Term Benefits
Patients who have been on semaglutide for an extended period have reported long-term benefits beyond weight loss. Many individuals have seen improvements in their overall health, such as better control of their blood sugar levels, reduced risk of heart disease, and increased energy levels. Semaglutide has also been shown to help with appetite control, making it easier for patients to maintain their weight loss over time.
Lisa, a patient who has been on semaglutide for over a year, shared her long-term benefits, stating, “Not only have I lost weight on semaglutide, but my blood sugar levels have stabilized, and my cholesterol levels have improved. I feel healthier and more in control of my health than ever before.”
These long-term benefits highlight the potential of semaglutide not only for weight loss but also for overall health improvements. It is essential to work closely with your healthcare provider to monitor your progress and make any necessary adjustments to optimize the benefits of semaglutide.
Final Thoughts
In conclusion, semaglutide has shown promise as a weight loss medication, with many patients reporting positive results such as significant weight loss, improved health markers, and increased energy levels. While some individuals may face challenges and side effects, with proper management and support from healthcare providers, these obstacles can be overcome. The long-term benefits of semaglutide extend beyond weight loss, offering patients a chance to improve their overall health and well-being. If you are considering trying semaglutide for weight loss, be sure to consult with your healthcare provider to discuss if it is the right option for you and to receive guidance on how to maximize its benefits.
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In this video, we explore the intriguing phenomenon known as 'Ozempic feet'—a side effect of GLP-1 medications like Ozempic, Wegovy, and Zepbound. Discover how rapid weight loss can lead to noticeable changes in foot appearance and function, as explained by medical experts. We discuss the implications of these changes, including discomfort and mobility issues, and provide tips on how to manage foot health during weight loss. Join us as we delve into the science behind these medications and their effects on the body, featuring insights from endocrinologists and real-life experiences. Don't forget to like, share, and subscribe for more health-related content!
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