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GLP-1 agonist drugs (like Ozempic, Wegovy, Trulicity, and Mounjaro) work by mimicking the effects of the natural hormone GLP-1 (glucagon-like peptide-1). These drugs are used primarily for type 2 diabetes and weight loss. Here’s a breakdown of how they work: ⸻ How GLP-1 Agonists Work in the Body GLP-1 is a hormone produced in the gut in response to food intake. It plays a major role in blood sugar regulation and appetite control. 1. Stimulate Insulin Release (Glucose-dependent) • GLP-1 agonists increase insulin secretion from the pancreas, but only when blood sugar is elevated. • This helps lower blood sugar after meals. 2. Suppress Glucagon Secretion • Glucagon is a hormone that raises blood sugar by signaling the liver to release glucose. • GLP-1 drugs reduce glucagon levels, decreasing sugar production by the liver. 3. Slow Gastric Emptying • These drugs delay how fast the stomach empties food into the intestines. • This leads to: • Slower absorption of glucose • Reduced post-meal blood sugar spikes • A longer-lasting feeling of fullness 4. Reduce Appetite via Brain Signaling • GLP-1 receptors are also found in the brain. • These drugs act on appetite centers, decreasing hunger and food intake, which can lead to weight loss.
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