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Lizzo debuted a must-see blonde hair transformation at the 2025 Met Gala May 5th. Full Story: https://www.eonline.com/news/1416665/inside-lizzos-body-transformation-journey?query=lizzo #enews #lizzo #metgala2025 About: The E! News team brings you the latest breaking entertainment, fashion and Pop Culture news. Featuring exclusive segments, celebrity highlights, trend reports and more, the E! News channel is the only destination Pop Culture fans need to stay in the know. Subscribe here: http://bit.ly/enewssub Connect: For More News - https://eonline.us/3MASskW E! News App - https://eonline.onelink.me/yMtl/4ead5017 Shopping - https://eonline.com/news/shop Facebook - https://www.facebook.com/enews/ Instagram - https://www.instagram.com/enews/ X - https://x.com/enews/ TikTok - https://tiktok.com/@enews

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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt

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GoKeto BHB Gummies are packed with exogenous ketones, specifically beta-hydroxybutyrate (BHB), which help to kickstart ketosis in your body. When you are in a state of ketosis, your body burns fat for energy instead of carbohydrates, leading to greater fat loss and increased energy levels. These gummies make it easy to get the benefits of BHB without the need to follow a strict keto diet.

Furthermore, the gummies are also formulated with natural ingredients that are safe and effective for most people. The formula is gluten-free, dairy-free, and non-GMO, making it suitable for a wide range of dietary needs. Additionally, the gummies are easy to take on the go, making it convenient to stay on track with your keto diet wherever you are.

Many users of GoKeto BHB Gummies have reported experiencing increased mental clarity and focus after incorporating the gummies into their daily routine. This can be attributed to the ketones in the gummies crossing the blood-brain barrier and providing the brain with a clean source of energy. This mental boost can help you stay sharp and focused throughout the day.

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One of the best things about GoKeto BHB Gummies is how easy they are to incorporate into your daily routine. Simply take the recommended dose of gummies each day, typically two to four gummies, depending on your individual needs. You can take them with or without food, making it easy to remember to take them consistently.

For best results, it is recommended to pair the gummies with a healthy and balanced keto diet. Focus on eating high-fat, moderate-protein, and low-carb foods to support your body’s transition into ketosis. Regular exercise can also help to enhance the effects of the gummies and accelerate your weight loss journey.

It is important to note that while GoKeto BHB Gummies can be a helpful supplement for your keto diet, they are not a magic solution for weight loss. Consistency and dedication to your diet and exercise routine are key to seeing results. Be patient with yourself and trust the process as your body adjusts to the changes.

Conclusion

GoKeto BHB Gummies are a fantastic option for anyone following a keto diet or looking to support their weight loss journey. With their convenient form, delicious taste, and powerful blend of BHB ketones, these gummies can provide the boost you need to reach your goals. Incorporate them into your daily routine alongside a healthy diet and exercise plan for best results. Try GoKeto BHB Gummies today and experience the benefits for yourself!

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Frequently Asked Questions

Q: Are GoKeto BHB Gummies safe to use?

A: Yes, GoKeto BHB Gummies are made with natural ingredients and are generally safe for most people to use. However, if you have any underlying health conditions or concerns, it is always best to consult with a healthcare professional before starting any new supplement.

Q: How quickly can I expect to see results with GoKeto BHB Gummies?

A: Results can vary depending on individual factors such as diet, exercise, and metabolism. Some people may experience results within a few weeks of consistent use, while others may take longer. It is important to be patient and stay consistent with your routine.

Q: Can I take GoKeto BHB Gummies if I am not following a keto diet?

A: While GoKeto BHB Gummies are designed to support a keto diet, they can still be beneficial for those not following a strict keto diet. The BHB ketones in the gummies can help to boost energy levels and support fat burning, regardless of your current diet.