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(12 Feb 2025) RESTRICTION SUMMARY: ASSOCIATED PRESS ARCHIVE: Hillerod, Denmark - 26 September 2023 1. Close of diabetes drug Ozempic in packaging line 2. Wide of diabetes drug Ozempic in packaging line ASSOCIATED PRESS ARCHIVE: Paris – 19 June 2024 3. Close up of wine tasting in the Caves du Louvre wine cellars ASSOCIATED PRESS Baltimore - 12 February 2025 4. SOUNDBITE (English) Dr. Lorenzo Leggio, NIH researcher: "The study is very important because it does add additional information on the potential role of semaglutide in GLP-1 medications for alcohol craving and alcohol drinking. So far, most of the evidence we hear is coming from pre-clinical studies and also from human data looking at electronic medical records. This study is very important because it's adding additional new information via double blind, placebo controlled clinical studies. So we determined important gaining knowledge in this specific topic in the field." ASSOCIATED PRESS ARCHIVE: Temecula, California – 30 April 2024 5. STILL: Wegovy injectable pens ASSOCIATED PRESS ARCHIVE: Front Royal, Virginia – 1 March 2024 6. STILL: Donna Cooper holds up a dosage of Wegovy, a drug used for weight loss, at her home ASSOCIATED PRESS ARCHIVE: Munich - 21 September 2024 7. Close up of person drinking beer ASSOCIATED PRESS Baltimore - 12 February 2025 8. SOUNDBITE (English) Dr. Lorenzo Leggio, NIH researcher: "The mechanism of action, how this medication works to make people craving less alcohol, and drinking less is not fully understood. We believe it's related to the ability of these medications to reduce the rewarding properties of alcohol. So what we call liking, wanting. However, we cannot discount the additional alternative mechanism that we don't know yet." ASSOCIATED PRESS ARCHIVE: Hillerod, Denmark - 26 September 2023 9. Various of diabetes drug Ozempic going through automated packaging line at Novo Nordisk production facility ASSOCIATED PRESS Baltimore - 12 February 2025 10. SOUNDBITE (English) Dr. Lorenzo Leggio, NIH researcher: "So this clinical trial is very promising. However, we do need more clinical trials. We need the larger clinical trials, and we need the clinical trials with people treated with these medications for a longer time. So as of now, we cannot claim yet that this medications work. As of now, we can say that it's possible that this medications work, but more research is needed." ASSOCIATED PRESS ARCHIVE: Hillerod, Denmark - 26 September 2023 11. Various of diabetes drug Ozempic going through automated packaging line at Novo Nordisk production facility ASSOCIATED PRESS Baltimore - 12 February 2025 12. SOUNDBITE (English) Dr. Lorenzo Leggio, NIH researcher: "This study is a very important step into the right direction to provide the more clinical trial based evidence to understand if these medications work for addiction, including alcoholic disorder." ASSOCIATED PRESS ARCHIVE: Pyongyang, North Korea - 13 December 2024 13. People drinking Taedonggang beer ASSOCIATED PRESS ARCHIVE: Front Royal, Virginia – 1 March 2024 14. STILL: Doses of Wegovy, a drug used for weight loss, are stored in a refrigerator ASSOCIATED PRESS ARCHIVE: Temecula, California – 30 April 2024 15. STILL: Stack of Wegovy boxes STORYLINE: Medications that have transformed the treatment of obesity may also help people drink less alcohol, according to new government-funded research. The research, published Wednesday in the journal JAMA Psychiatry, was funded by the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health. Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/e1c713c18fd64dd6a3598dbb7238d717

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Semaglutide is a medication that has been gaining attention for its potential to aid in weight loss. With obesity rates on the rise globally, finding effective ways to manage weight has become a top priority for many individuals. Semaglutide is a promising option for those looking to shed excess pounds and improve their overall health.

The Science Behind Semaglutide

Semaglutide works by mimicking the effects of a hormone called GLP-1, which is naturally produced in the body. GLP-1 helps regulate insulin levels, appetite, and digestion. By activating GLP-1 receptors in the brain, semaglutide can help reduce feelings of hunger and increase feelings of fullness. This can lead to reduced food intake and ultimately, weight loss.

In addition to its effects on appetite, semaglutide also has a positive impact on metabolism. It can help increase the body’s sensitivity to insulin, which means cells are better able to take up glucose from the bloodstream. This can lead to improved blood sugar control and potentially, weight loss.

Studies on Semaglutide and Weight Loss

Several clinical trials have looked at the effectiveness of semaglutide for weight loss. One study published in The New England Journal of Medicine found that participants who took semaglutide lost an average of 15% of their body weight over 68 weeks. This was significantly more than the placebo group, who only lost 2.4% of their body weight.

Another study published in JAMA found that semaglutide was associated with an average weight loss of 10-20% among participants who were obese or overweight. These results suggest that semaglutide can be a powerful tool for combating obesity and its associated health risks.

Potential Side Effects of Semaglutide

While semaglutide has shown promising results for weight loss, it is important to be aware of potential side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary, but some individuals may experience more severe reactions.

In rare cases, semaglutide can cause inflammation of the pancreas or thyroid, which can be serious. It is important to discuss the potential risks and benefits of semaglutide with a healthcare provider before starting treatment. Monitoring for any unusual symptoms is also recommended while taking this medication.

Is Semaglutide Right for You?

If you are struggling to lose weight and have not had success with other methods, semaglutide may be worth considering. It is typically prescribed to individuals who have a BMI of 30 or higher, or a BMI of 27 or higher with weight-related health conditions such as diabetes or high blood pressure.

Before starting semaglutide, it is important to have a thorough discussion with your healthcare provider about your weight loss goals, medical history, and any potential risks associated with the medication. They can help determine if semaglutide is a good fit for you and provide guidance on how to use it effectively.

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