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Meet Los Angeles Addictionologist Dr. Jason Giles! His own journey with addiction led him to specialize in addiction medicine. Hear his thoughts on the potential of GLP-1s for treating substance abuse—how they affect cravings, brain chemistry, and what that could mean for the future of addiction treatment. Bonus episode out now! #addiction #GLP1s #weightloss #medicalweightloss #addictionologist #semaglutide #tirzepatide

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Welcome back to the CardioNerds Cardiovascular Prevention Series, where we are continuing our discussion of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs). This class of medications is becoming a household name, not only for their implications for weight loss but also for their effect on cardiovascular disease. CardioNerds Dr. Ty Sweeney (CardioNerds Academy Faculty Member and incoming Cardiology Fellow at Boston Medical Center), Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at Johns Hopkins Hospital), and special guest Dr. Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr. Darren McGuire (Cardiologist at UT Southwestern and Senior Editor of Diabetes and Vascular Disease Research) to discuss important trial data on GLP-1 RAs in patients with heart disease, as well as recent professional society guidelines on their use. Show notes were drafted by Dr. Ty Sweeney. Audio editing was performed by CardioNerds Intern student Dr. Diane Masket. If you haven’t already, be sure to check out CardioNerds episode #350 where we discuss the basics and mechanism of action of GLP-1 RAs with Dr. Dennis Bruemmer. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Diving into the Data Patients with diabetes and clinical atherosclerotic cardiovascular disease (ASCVD) or who are at high risk of ASCVD benefit from treatment with a GLP-1 RA. For persons with sufficient ASCVD risk and type 2 diabetes, GLP-1 RAs and SGLT2 inhibitors can, and often should, be used in combination. "Just like we don’t consider ‘and/or’ for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldn’t parcel out these two therapeutic options...it should be both.” Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs. Utilize a multidisciplinary approach when caring for patients on GLP-1 RAs. Build a team with your patient’s primary care provider, endocrinologist, clinical pharmacist, and nurse. “This is really a cardiologist issue. These are no longer endocrinology or primary care drugs. We need to be prescribing them ourselves just like we did back in the nineties when we took over the statin prescriptions from the endocrinology domain...we need to lead the way.” Show notes - GLP-1 Agonists: Diving into the Data For which patients are GLP-1 RAs recommended to reduce the risk of major cardiac events? For patients with type 2 diabetes and ASCVD, starting a GLP-1 RA carries a Class 1, Level of Evidence A recommendation in the most recent ESC and ACC guidelines. For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk. The STEP-HFpEF trial showed that among patients with obesity and HFpEF, once-weekly semaglutide may be beneficial in terms of weight loss and quality of life. The results of the FIGHT and LIVE trials question the utility and safety of liraglutide in treating patients with advanced HFrEF. Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF. Stay tuned for sub-analyses from that trial for more info! Can we still prescribe GLP-1 Ras in patients with well-controlled T2DM?

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**Summary/Frequently Asked Questions:**

Is Opti Burner Keto Gummies safe to use?

Yes, Opti Burner Keto Gummies are made with natural ingredients and are safe for most individuals to use. However, it’s always a good idea to consult with a healthcare professional before starting any new supplement regimen.

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How soon will I see results with Opti Burner Keto Gummies?

Results may vary, but many users experience noticeable results within a few weeks of consistent use. Remember to combine these gummies with a healthy diet and exercise routine for maximum effectiveness.

Can I take Opti Burner Keto Gummies if I have dietary restrictions?

Opti Burner Keto Gummies are gluten-free and suitable for most dietary restrictions. However, if you have specific concerns, it’s best to check the ingredients list or consult with a healthcare professional.

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12 WEEK TRANSFORMATION CHALLENGE! http://muscularstrength.com/twelve-week-transformation-challenge Easiest Bodyfat Measuring Tool! - SKULPT AIM: http://goo.gl/hvapTN High Protein Food! - Pasta, Oatmeal, Granola, and Snack Bars! - http://muscularstrength.com/true-gains Website: http://www.MuscularStrength.com/join (ONE MONTH FREE - PROMOCODE: FREEFITNESS) FX-SPORT Headphones (Wireless & Waterproof!) Use code SCOTT20 for $20 off - http://goo.gl/0YNmyU Bar Grips, Wrist Wraps/Straps, Fractional Plates & More! - IronBullStrength - 10% off coupon code! "MS10" - CLICK HERE - http://goo.gl/b05PxB Online Coaching (Custom Routine & Meal Plan) http://muscularstrength.com/consultations Fitness Genes - Maximize YOUR Genetic Potential! - CLICK HERE (30% Off) - https://goo.gl/FSBMWc THYNC - Want To Sleep Better & Focus More During Your Workouts? - http://goo.gl/BwYlxZ Twitter: https://www.twitter.com/Scott_Herman Facebook: http://www.facebook.com/ScottHermanFitness Instagram: http://www.instagram.com/ScottHermanFitness (1:31)- Landon Petermann Hey Scott and Sean, I've been the workouts on SHF workouts and have seen awesome improvement with strength, but I also want to lose body fat and gain muscle mass. I have been doing the drop set system; it seems to be working but only for muscle strength. I'm in BJJ (Jiu-Jitsu) so muscle gain and strength is a great thing to have. I'm 17 and 6'1" with 30% body fat (20% back fat, and 10% arm fat). I'd like to have way less body fat just like everyone else does, but the question is how can I lose body fat all the way around and gain muscle mass at the same time with only a bench press, workout ball, lat pull down, incline press, and curl bar? Also you two are beasts! And in advance thanks Scott and Sean! (7:38)- Frankie Schel Hey guys, I've seen some of your video's on supplements before, but I was just wondering what your opinions are on HGH (human growth hormone) supplements. I've seen some people refer to them as a steroid, but a lot of research I've seen on them say they're "all natural". • Have you guy's taken them? • Do you recommend them, or not? • What do you know about them? • Are they worth taking? • Are they safe to take? • Is there one you'd recommend? • etc... (14:32)- Lucas- England. Hey Sean & Scott (Sean deserves to be first sometimes haha) Anyway quick question, generally my posture is pretty good, however my shoulders slouch forward just a bit, anyway to combat this? I presume its maybe because I work my chest harder than my back/shoulders. Any tips to bring them back a bit and make everything a bit tighter round my shoulder region? Would it be a case of just thinking about it and sort of forcing them back to correct it? I've been working out over a year, but 6 months seriously. My meal plan is pretty good, and I'm not taking any supplements at the minute. If it matters, I'm 19, 6ft and my weight fluctuates between 84-87 kgs (185lbs - 191lbs). Not sure about my body fat % but I think I'm pretty lean. Also another quick question I have a bit of fat on my stomach, just hiding my abs, I'm currently doing a circuit which involves my back to lose it, is this effective. It consists of: 8-10 reps upright row, 8-10 reps bent over row, 8-10 reps deadlift, 8-10 reps standing barbell shoulder press and then 8-10 reps good mornings. Obviously all those exercises one after another after on circuit then a 45 second to a minute break, and I do this for 5 circuits. Thanks for the help, Lucas, England.