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This is an excerpt of the keynote 'Current Status and Potential Future of Obesity Therapies' by Associate Vice President James Trevaskis (Eli Lilly) at the conference Metabolism Day 2025. He provides an insightful overview of the current obesity therapeutics landscape and future innovations beyond GLP-1 receptor agonists, discusses the evolution of obesity treatments, highlights the success of GLP-1s like semaglutide and tirzepatide, while exploring emerging therapies including: Retatrutide - Eli Lilly's tri-agonist (GIP/GLP-1/glucagon) showing up to 24% weight loss Small molecule GLP-1 agonists - Oral alternatives like orforglipron Amylin-based therapies - The next major non-incretin class for obesity treatment Combination approaches - Including activin receptor inhibitors to preserve lean muscle mass during weight loss Trevaskis addresses key challenges in obesity drug development, including patient response variability, body composition changes, and the need for novel biological targets. He also shares Eli Lilly's innovative CRISPR-based approach for rapid target validation in obesity research. This talk offers valuable insights into the future of obesity medicine, discussing both the promise and challenges of developing more effective, personalized treatments for metabolic disease.

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Our full interview with Deborah Evans. We spoke to Deborah Evans about GLP-1 receptor agonists – the fat jabs – and what we have learned over the past 12-18 months. Read, watch and listen here - https://medicalupdateonline.com/2025/03/glp-1-ras-where-are-we-now-what-have-we-learned/?utm_source=youtube&utm_medium=social&utm_campaign=organic Register on our website for news straight to your inbox - https://medicalupdateonline.com/register/ This episode of ‘In Discussion With’ is also on Spotify. Listen to the full podcast now - https://creators.spotify.com/pod/show/medicalupdateonline/episodes/GLP-1-RAs--where-are-we-now--What-have-we-learned-e300s0f 0:00 - Introduction, titles & roles 1:24 - Are GLP-1 RAs easy & safe for weight loss? 3:08 - Differences - semaglutide vs. tirzepatide 6:31 - Side-effects of GLP-1 RAs 8:33 - Serious side-effects of GLP-1 RAs 10:07 - How to get GLP-1 RAs 12:27 - GLP-1 RAs via the NHS 14:54 - Additional support for patients 16:03 - Incorrect GLP-1 RA prescribing 18:02 - Counterfeit GLP-1 RAs 19:37 - Short-term use of GLP-1 RAs? 24:06 - Should you take GLP-1 RAs for life? 25:12 - Risks of sarcopaenia and osteoporosis 28:19 - Dose optimisation 30:34 - Tolerability variations 31:24 - Dose individualisation 33:20 - GLP-1 RA drug switching 35:58 - GLP-1 RA non-responders 37:24 - Starting GLP-1 RAs – what to expect 40:02 - Do we eat too much? 42:39 - Value of GLP-1 RA weight loss 43:56 - Possible anaesthetic risk 46:49 - Outro This interview was recorded on 06/02/2025. ___ Keep up to date with us across our network; Email us at - [email protected] Site - https://medicalupdateonline.com/ Twitter - https://twitter.com/medupdateon1ine Instagram - https://www.instagram.com/medicalupdateonline Facebook - https://www.facebook.com/medupdateonline LinkedIn - https://www.linkedin.com/company/medicalupdateonline This content is for informational purposes only, and does not replace the advice of your own doctor or healthcare professional. Copyright © 2022 MedicalUpdateOnline. IMI (a trading name of ICR UK Limited) is a digital communications agency that specialises in the pharmaceutical and medical industries. IMI was founded in 2003 by the current CEO Peter Mas-Mollinedo, a pharmacist and forward-thinking entrepreneur. IMI’s primary activities include the production of medical educational journals and bulletins, medical conference coverage and video interviewing of health care professionals worldwide to disseminate information such as trial results, new products, research, drug approvals, new accreditations, etc. It is a trusted provider of medical information to its extensive database of medical health care professionals in the UK, Europe and beyond. To find out more about IMI, please see our websites www.medicalupdateonline.com and www.medicalimi.com. Alternatively, you can email us at [email protected].

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