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Drs Akshay Jain and Lorenzo Leggio discuss GLP-1 RA therapy and its potential to mitigate alcohol misuse syndrome. https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt --TRANSCRIPT-- Akshay B. Jain, MD: Today we are very excited to have Dr Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Jain: We'll get right into this. Your session was, in my mind, extremely informative. The session looked at glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy and its potential effects on mitigating alcohol misuse syndrome, so, reduction of alcohol addiction potentially. We've seen in some previous clinical trials, including many from your group, that alcohol use is known to be reduced — the overall risk of incidence, as well as recurrence of alcohol use — in individuals who are on GLP-1 RA therapy. Can you share more insights about the data already out there? Leggio: At the preclinical level, we have a very robust line of studies, experiments, and publications looking at the effect of GLP-1 RAs, starting from exenatide up to, more recently, semaglutide. They show that these GLP-1 RAs do reduce alcohol drinking. They used different animal models of excessive alcohol drinking, using different species — for example, mice, rats, nonhuman primates — models that reflect the excessive alcohol drinking behavior that we see in patients, like physical alcohol dependence or binge-like alcohol drinking, and other behaviors in animal models that reflect the human condition. In addition to that, we recently have seen an increase in human evidence that GLP-1 RAs may reduce alcohol drinking. For example, there is some anecdotal evidence and some analyses using social media showing that people on GLP-1 RAs report drinking less alcohol. There are also some pharmacoepidemiology studies which are very intriguing and quite promising. In this case, people have been looking at electronic medical records; they have used the pharmacoepidemiology approaches to match patients on GLP-1 RAs because of diabetes or obesity, and have compared and matched to patients on different drugs as the controls. A study was recently published in Nature Communications by a group in Cleveland in collaboration with Dr Nora Volkow from the National Institute on Drug Abuse. This study shows the association between being on a GLP-1 RA and the lower incidence of alcohol use disorder and lower drinking. There is also some promise from prospective randomized clinical trials. In particular, there was one clinical trial from Denmark, a well-known and -conducted clinical trial where they looked at exenatide, and they didn't see an effect of exenatide compared with placebo in the main analysis. But in a subanalysis, they did see that exenatide reduced alcohol drinking, but only in patients with alcohol use disorder and obesity. This suggests that these medications may work for some patients and not for other patients. That's fine, because just like in any other field in medicine, including diabetes, obesity, hypertension, Parkinson's, and depression, not all medications work for everybody. If these medications will work for alcohol addiction, we do not expect that they will work for everybody. One ongoing question in the field is to try to identify the phenotypes or the subgroup of people who may be more responsive to these medications. Jain: This is such a fascinating field, and all these studies are coming out. In your review of all the literature so far, do you think this is dose dependent? Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects. Recent studies have shown that the rate of these GI side effects does not necessarily correlate with the amount of weight loss. In the alcohol addiction field, do you think that the GI side effects, things like nausea, could also have a potential role in mitigating the alcohol addiction? Leggio: This is a great question. They may play a role; they may contribute, too, but we don't think that they are the driving mechanism of why people drink less, for at least a couple of reasons. One is that, similar to the obesity field, the data we have so far don't necessarily show a relationship between the GI side effects and the reduction in drinking. Plus, the reduction in drinking is likely to happen later when many GI side effects are gone or attenuated. Transcript in its entirety can be found by clicking here: https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt
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Are you looking for a delicious and convenient way to support your keto diet and weight loss goals? Keto gummies have become increasingly popular in the health and wellness industry as a tasty alternative to traditional supplements. But are keto gummies actually effective in helping you lose weight, or are they just another trendy fad? In this article, we will explore the legitimacy of keto gummies as a weight loss solution.
The Science Behind Keto Gummies
Keto gummies are a type of supplement that is specifically formulated to support the keto diet. They are usually made with ingredients such as exogenous ketones, MCT oil, collagen, and other nutrients that are beneficial for those following a low-carb, high-fat diet. These gummies are designed to help you stay in ketosis, burn fat for energy, and curb cravings for sugary snacks.
Exogenous ketones are a key ingredient in keto gummies. These ketones are synthesized outside the body and can help elevate your ketone levels, making it easier to reach and maintain ketosis. By consuming exogenous ketones in the form of gummies, you may experience increased energy, mental clarity, and improved fat burning, which can all contribute to weight loss.
MCT oil is another common ingredient found in keto gummies. MCTs, or medium-chain triglycerides, are a type of fat that is easily digested and converted into ketones by the liver. This can help boost your ketone levels and support your weight loss efforts. Additionally, MCT oil is known to improve satiety and increase energy expenditure, making it a valuable addition to keto gummies.
Benefits of Keto Gummies
There are several potential benefits to incorporating keto gummies into your weight loss journey. Firstly, they provide a convenient and portable way to supplement your diet with essential nutrients and ketones. This can be especially helpful for busy individuals who may not have time to prepare keto-friendly meals or snacks throughout the day.
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Additionally, keto gummies are a tasty alternative to traditional supplements, making them more enjoyable to consume. This can help you stay consistent with your supplement regimen and prevent you from feeling like you are depriving yourself of sweets while on the keto diet. By satisfying your sweet tooth with keto gummies, you may be less likely to indulge in high-carb treats that could derail your weight loss progress.
Another benefit of keto gummies is their potential to boost your energy levels and improve your overall well-being. The exogenous ketones and MCT oil found in these gummies can help enhance mental clarity, focus, and physical performance, which can be especially beneficial during workouts or when following a strict keto diet. By supporting your body with the nutrients it needs, you may experience increased vitality and motivation to stick to your weight loss goals.
Are Keto Gummies a Legitimate Weight Loss Solution?
While keto gummies may offer several benefits for individuals on the keto diet, it is important to remember that they are not a magic solution for weight loss. In order to effectively lose weight and maintain a healthy lifestyle, it is essential to incorporate a balanced diet, regular exercise, and other healthy habits into your routine. Keto gummies should be viewed as a supplement to support your overall weight loss goals, rather than a quick fix or replacement for a nutritious diet.
Ultimately, the legitimacy of keto gummies as a weight loss solution will depend on how they are used in conjunction with a healthy lifestyle. If you are already following a keto diet and looking for a convenient way to enhance your results, keto gummies may be a beneficial addition to your routine. However, it is important to remember that sustainable weight loss requires a holistic approach that includes proper nutrition, physical activity, and mindfulness.
Before incorporating keto gummies into your weight loss regimen, it is recommended to consult with a healthcare provider or nutritionist to ensure that they are suitable for your individual needs and goals. By making informed choices and taking a comprehensive approach to weight loss, you can maximize your chances of success and achieve long-lasting results.
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There’s a BIG misconception that high-intensity cardio is the best way to burn fat… but that’s only part of the picture. Yes, HIIT burns calories fast—but mostly from carbs. If your goal is sustainable fat loss, you need to train smarter, not just harder. Enter LISS (Low-Intensity Steady-State) cardio. LISS taps into fat stores more efficiently, is easier on your joints, and won’t wreck your recovery like daily HIIT might. It’s the secret weapon for long-term leanness—especially when paired with proper lifting and a calorie deficit. If fat loss is the mission, lock in on this formula: ✅ Eat in a calorie deficit ✅ Prioritize LISS cardio (daily if you can) ✅ Do it AFTER your weight training Need a proven protocol? Hop on a treadmill: Incline: 10 | Speed: 3.0 | Duration: 30 minutes | Frequency: 5x/week Do that consistently and you’ll notice the fat start falling off—without burning out or breaking down. Train smart. Stay consistent. Trust the process. Save & share with someone who needs to hear this🫱🏽🫲🏾✅ 🏷️#fitness #fatloss #caloriedeficit #fitnessjourney #gymtips #cardio #inclinewalking #bodybuilding #gymbro
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