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Join Drs Nihar Desai and Matthew Cavender as they discuss the history, studies, and implementation of GLP-1 receptor agonists for people with cardiorenal metabolic syndrome. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999842. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Glucagon-Like Peptide-1 Receptor Agonists https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20(,options%20for%20these%20endocrine%20diseases. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death From Cardiovascular Causes https://pubmed.ncbi.nlm.nih.gov/17517853/ Guidance for Industry on Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes; Availability https://www.federalregister.gov/documents/2008/12/19/E8-30086/guidance-for-industry-on-diabetes-mellitus-evaluating-cardiovascular-risk-in-new-antidiabetic Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27295427/ Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease: Design and Baseline Characteristics of SOUL, a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/36945734/ Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/ Heart Failure With Preserved Ejection Fraction (HFpEF) https://www.ncbi.nlm.nih.gov/books/NBK599960/ Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/27483064/ Semaglutide Versus Placebo in People With Obesity-Related Heart Failure With Preserved Ejection Fraction: A Pooled Analysis of the STEP-HFpEF and STEP-HFpEF DM Randomised Trials https://pubmed.ncbi.nlm.nih.gov/38599221/ Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/33183512/ Comparison of Tirzepatide and Dulaglutide on Major Adverse Cardiovascular Events in Participants With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: SURPASS-CVOT Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/37758044/ Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/36877177/

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In this powerful episode, I sit down with Dr. Paul Kolodzik, MD, founder of MetabolicMD and a double board-certified physician specializing in medical weight loss and metabolic health. We dive into cutting-edge strategies for weight loss that go far beyond calorie counting—focusing on the use of GLP-1 medications, continuous glucose monitors (CGMs), and a low-carb nutritional approach to improve insulin resistance, reverse pre-diabetes, and tackle stubborn weight gain. Dr. Kolodzik shares expert insights into how low-dose GLP-1 medications can be used safely, potential side effects, and how personalized, data-driven care can dramatically improve outcomes. Whether you're struggling with weight loss, metabolic syndrome, or simply want to understand your body better, this episode is packed with science-backed, actionable information. 🔬 Learn how the future of weight loss is here—with continuous monitoring, physician guidance, and real food that fuels your health. Connect with Barbara: Online Coaching: https://www.trainerize.me/profile/barbara-holistic-nutritionist/Barbara.Karafokas/ Website: www.barbarakarafokas.com LinkedIn: / barbara-karafokas-03ab0932 X: @ themedlifediet