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#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an “anti-hunger” molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. “Until now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,” said Jonathan Long, PhD, an assistant professor of pathology. “Now we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.” The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. “It was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.” said Long. “These findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. I think what we’re seeing now is just the beginning of new types of weight loss drugs.” Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Have you been considering trying the ketogenic diet but don’t know where to start? Look no further than GoKeto Gummies! These delicious gummies are the perfect way to support your keto lifestyle while satisfying your sweet tooth. But before you make a purchase, it’s important to understand how to navigate the official GoKeto Gummies website. In this article, we will guide you through the process of purchasing GoKeto Gummies directly from the source.

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When you first visit the official GoKeto Gummies website, you’ll be greeted with a sleek and user-friendly interface. The homepage features vibrant images of the gummies, along with information about their benefits and ingredients. Take some time to explore the different sections of the website to familiarize yourself with the product and its offerings.

One of the most important pages on the GoKeto Gummies website is the product page. Here, you’ll find detailed information about the gummies, including their nutritional content, flavor options, and pricing. You can also read customer reviews to see what others have to say about their experience with GoKeto Gummies.

Another key feature of the GoKeto Gummies website is the checkout process. When you’re ready to make a purchase, simply add the desired quantity of gummies to your cart and proceed to the checkout page. Here, you’ll be prompted to enter your shipping and payment information. Rest assured that the website uses secure encryption to protect your personal data.

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Shipping times may vary depending on your location. In general, orders within the United States typically arrive within 5-7 business days. International orders may take longer to arrive due to customs regulations.

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While GoKeto Gummies are low in sugar and carbohydrates, it’s always best to consult with your healthcare provider before starting any new dietary supplement, especially if you have specific dietary requirements such as diabetes.

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Have you had issues with successfully dieting to lose fat and gain muscle at the same time? Well, it may be due to a few common dieting mistakes that I see people make, which affects their ability to not only lose fat and build muscle (body recomposition) but also keep muscle when dieting in the first place. One of the top dieting mistakes people make is actually losing weight too aggressively. Because when it comes to how to maintain muscle while cutting and even building muscle while losing fat, you need to supply your body with enough energy and nutrients to do so. For example, a well-known 2011 paper found that the group of subjects placed on a ‘fast diet’ (ate 300 fewer calories daily) lost significantly less fat than the slow group, and they also lost a little bit of muscle mass as well. On the other hand, the slow group was actually able to gain a little bit of muscle, gained significantly more strength, and lost a more significant amount of fat as well. So what I’d suggest is to aim to lose around 0.5-1% of your body weight per week, but this does depend on your current level of body fat. The second dieting mistake most people make when wanting to keep or build muscle and lose fat is simply doing too much too soon at the start of the diet. But this approach actually prevents you from having any leverage when you reach a fat loss plateau. When you start dieting and put your body in a calorie deficit, over time, your body compensates by decreasing its metabolism to burn fewer calories. Which eventually leaves you stuck in a fat loss plateau since your metabolism has reduced to the point where you're no longer in a calorie deficit to lose fat. But the problem is, if you’re already starving yourself and doing a ton of cardio, you’re unable to push further to break through this plateau. So instead, for optimal body recomposition, you want to first start at a small to moderate calorie deficit of roughly 10-20% or 500 calories below your maintenance, for example. And you also want to start with minimal cardio, so for instance 1-2 low-intensity sessions per week. Then, as the weeks go by and your weight and fat loss begins to stagnate, you can simply drop your calories further and/or increase your cardio slightly as needed to break through these plateaus every time you reach them. The last mistake when it comes to a diet to how to lose fat without losing muscle is not taking breaks with your calorie deficit. The longer you diet for the more your body begins to physiologically adapt to both slow down your fat loss and make you more prone to losing muscle. To reverse this effect, you can make use of a strategy known as ‘diet break’ where you increase your calories back to maintenance for a week or two during your diet. What I'd recommend for a similar effect is simply implementing a one-week diet break after every 4-8 weeks or so of dieting. This way, you'll avoid increasing the length of your diet too much while still getting the many benefits that diet breaks have to offer. So as you may have noticed guys, when it comes to maintaining your muscle during a diet or how to lose fat and gain muscle at the same time, you need to avoid rushing the process and instead slow it down by using a more controlled and systematic approach. And if you’re looking for a step-by-step program that shows you exactly how to implement this with both your workouts and your nutrition, such that you can lean down while improving your muscle definition and strength, take the analysis quiz below to discover what science-based program best suits you and your starting point: https://builtwithscience.com/bws-free-fitness-quiz/gender?utm_source=Youtube&utm_medium=Video&utm_content=Description%20box&utm_campaign=Lose%20more%20fat%20keep%2Fbuild%20muscle%20Oct%2027%2F2019 Filmed by: Bruno Martin Del Campo MUSIC: Music by Ryan Little - fall so high. - https://thmatc.co/?l=F77E5E72 GRAPHICS: Vecteezy.com bonytobeastly.com FOLLOW ME: https://www.instagram.com/jeremyethier/ https://www.facebook.com/Jeremyethierfit/ STUDIES: FAST DIET VERSUS SLOW DIET https://www.ncbi.nlm.nih.gov/pubmed/21558571?fbclid=IwAR1FeLmsv1o2jidKj2l7aydCTvZF-uKmvxXPRI6sxfUYZCTn7WYFyPeA6U4 https://www.ncbi.nlm.nih.gov/pubmed/10865771?dopt=Abstract https://jissn.biomedcentral.com/articles/10.1186/1550-2783-11-20 DIET BREAK https://www.ncbi.nlm.nih.gov/pubmed/28925405 Subscribe to my channel here: https://www.youtube.com/jeremyethier/?sub_confirmation=1

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Alzheimer's disease is a devastating neurological disorder that affects millions of people worldwide. With no cure in sight, researchers have been exploring new avenues for treatment and prevention. One promising area of research is the potential role of GLP-1 in fighting Alzheimer's. GLP-1, or glucagon-like peptide-1, is a hormone that helps regulate blood sugar levels and has been shown to have neuroprotective effects. But can it really help combat Alzheimer's? In this video, we'll delve into the latest research on GLP-1 and its potential in preventing and treating Alzheimer's disease. From its mechanisms of action to the latest clinical trials, we'll explore the evidence and what it means for the future of Alzheimer's treatment. #glp1 #mounjaro #Wegovy #alzheimers #tirzepatide #answer #ozempic #weightloss #insulin #insulinresistance #brain #science #mentalhealth #mentalhealthawareness #cognitivefunction #cognitivehealth #neurology #neuroscience #memory #health#healthcare #brainhealth #alzheimer #alzheimersawareness #alzheimer #alzheimersprevention #diabetes #diabetic #diabeticos #diabetesawareness

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