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Could weight loss drugs lead to a paradox of dependency on new medications? GLP-1 drugs emerged in the early 2000s, originally for type-2 diabetes, now popular for weight loss.,These drugs are widely sought after for their effectiveness in reducing body fat.,However, GLP-1 drugs can lead to serious side effects like pancreatitis and loss of muscle mass.,Strength training is vital for individuals using GLP-1 drugs to maintain muscle and bone health.,Research suggests bimagrumab could counteract muscle and bone loss in users of GLP-1 drugs.,Animal studies showed that bimagrumab injections increased muscle mass and bone density in mice.,The research highlights potential benefits, but more human studies are needed for safety and efficacy.,This drug advancement may help those unable to exercise, but raises concerns about dependency on medication.,Is relying on drugs undermining essential lifestyle changes for sustainable weight management? #GLP1, #WeightLoss, #MuscleHealth, #Bimagrumab

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This is an excerpt of the keynote 'Current Status and Potential Future of Obesity Therapies' by Associate Vice President James Trevaskis (Eli Lilly) at the conference Metabolism Day 2025. He provides an insightful overview of the current obesity therapeutics landscape and future innovations beyond GLP-1 receptor agonists, discusses the evolution of obesity treatments, highlights the success of GLP-1s like semaglutide and tirzepatide, while exploring emerging therapies including: Retatrutide - Eli Lilly's tri-agonist (GIP/GLP-1/glucagon) showing up to 24% weight loss Small molecule GLP-1 agonists - Oral alternatives like orforglipron Amylin-based therapies - The next major non-incretin class for obesity treatment Combination approaches - Including activin receptor inhibitors to preserve lean muscle mass during weight loss Trevaskis addresses key challenges in obesity drug development, including patient response variability, body composition changes, and the need for novel biological targets. He also shares Eli Lilly's innovative CRISPR-based approach for rapid target validation in obesity research. This talk offers valuable insights into the future of obesity medicine, discussing both the promise and challenges of developing more effective, personalized treatments for metabolic disease.

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Speeding up fat loss effectively and safely involves a mix of nutrition, movement, and lifestyle adjustments. Here are the most practical, science-backed tips: 🔥 1. Prioritize Protein at Every Meal Keeps you full, supports muscle, boosts metabolism. ✅ Examples: Paneer, tofu, lentils, Greek yogurt, eggs, sprouts. 🥦 2. Cut Processed Carbs & Sugar Reduces insulin spikes and cravings. ❌ Avoid: white bread, bakery items, sugary drinks. ✅ Choose: oats, quinoa, whole fruits, sweet potatoes. 🏋️‍♀️ 3. Lift Weights or Do Resistance Training Preserves muscle while losing fat. Increases metabolism even at rest. 🚶‍♀️ 4. Increase NEAT (Daily Movement) Non-exercise activity thermogenesis: walking, cleaning, stairs. 📈 Aim for 7,000–10,000 steps/day. 💧 5. Stay Hydrated Sometimes thirst feels like hunger. Drink water before meals to reduce overeating. 🌙 6. Sleep 7–8 Hours Poor sleep increases hunger hormones (ghrelin). More likely to crave junk when tired. ⏳ 7. Try Intermittent Fasting (Optional) Helps control calorie intake. Common method: 16:8 (fast for 16 hrs, eat in 8-hr window). 📉 8. Maintain a Calorie Deficit You must eat fewer calories than you burn. But don’t starve — aim for 500–700 calorie deficit per day. 📵 9. Manage Stress High cortisol = belly fat, cravings, poor sleep. Try yoga, deep breathing, hobbies. ⚖️ 10. Be Consistent & Track Progress Use progress pictures, inches, or how clothes fit — not just weight. Fat loss isn’t linear, stay patient. #NaturalResults #fiber #WellnessWithTea #YogaForWellness #MindfulMovement #HealthyLiving #YogaEveryday #fitness #walking #videocall #consistency #swatijain #tipsofficial #healthychoices #healthylife #swatijain #behappywithhappylifestyle #ironrichfoods #cardio #walking #weightlossjourney #weightgain #transformation #dedication #workout #workoutmotivation #healthylifestyle #aminoacids #healthyfood #anemicproblems

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