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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts
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We completed Week 1 on WEGOVY This video is not sponsored I purchased the product at full price and all opinions are my own. Link to Products used in the video and for each purchase I receive a small commission that helps with the channel and Information: https://www.amazon.com/shop/itsstephanie https://direct.me/itsstephanie Buy Me a Coffee https://www.buymeacoffee.com/ItsStephanie Warning this video is not for children it requires equipment that should only be used by an adult. Please go follow me on my other pages Here are all my social media areas: https://www.facebook.com/stephanie.gordonmartinez/ https://twitter.com/Steph198827 https://www.instagram.com/steph.1103.sd/ If you would like to be featured, want to send a letter or have any business inquiries: Email: [email protected] Mailing Address: Stephanie Gordon P.O. Box 14466 Odessa TX 79768 For Cricut: https://shareasale.com/u.cfm?d=605569&m=51766&u=1963211&afftrack= Save 20% on Vinyl https://www.shareasale.com/u.cfm?d=712522&m=51766&u=1963211 Save on Cricut Machine tools https://www.shareasale.com/u.cfm?d=712524&m=51766&u=1963211 Take an extra 20% off our low bulk prices. https://www.shareasale.com/u.cfm?d=712527&m=51766&u=1963211 FREE Economy Shipping on orders $99+ to US and Canada. Promo Code: SHIPOCT https://www.shareasale.com/u.cfm?d=710730&m=51766&u=1963211 For each of the above Cricut links I receive a small commission for purchases made which help to support the Channel. All of the information in this video is my own personal opinion, YouTube, Cricut, Instant Pot and or any other company are not responsible or reliable for any of the information, opinions, or content of this Video.
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Kelly Clarkson's recent weight loss transformation has left fans wondering how the Stronger singer managed to drop 40lbs so quickly. Although many have speculated that she might have resorted to weight loss-aiding drugs like Ozempic and Wegovy. However, a source close to Clarkson has confirmed that the American singer did not resort to artificial methods, as per OK!. The Since You've Been Gone singer has been flaunting her slim physique, donning trendy outfits one after another on her famous talk show.
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A Journey of Transformation
In the realm of personal health and wellness, inspiring stories of transformation resonate deeply with countless individuals seeking to improve their lives. Among these narratives, Janelle Brown’s remarkable weight loss journey stands out, capturing the attention and admiration of many. In 2024, Janelle undertook an ambitious goal: to lose 100 pounds and completely overhaul her lifestyle. What made her journey particularly compelling was not just the weight loss itself, but the unique insights and experiences she shared along the way. Her story serves as an encouragement for those who may feel overwhelmed by their own struggles with weight and well-being. Janelle’s experience is a testament to the power of determination, resilience, and support in achieving personal goals.
Janelle Brown, known for her vibrant personality and commitment to self-improvement, decided to take control of her health after reflecting on her lifestyle and long-term wellness goals. Fatigue, health concerns, and a desire for greater energy levels were pivotal in her decision. As she embarked on this journey, Janelle documented her progress, sharing not only the physical changes she experienced but also the mental challenges she faced. This honesty has inspired many to approach their own health journeys with a mindset focused on growth, rather than just a number on the scale.
The transformation journey encompassed various aspects of life, including nutrition, physical activity, mental health, and emotional well-being. Janelle’s approach was holistic; she understood that true change must address both the body and the mind. In the ensuing sections, we will delve deeper into the various components of Janelle’s journey, examining her strategies, the role of community support, and the ultimate lessons learned along the way. This in-depth exploration provides not just an account of weight loss but a beacon of hope and motivation for anyone wishing to change their life for the better.
Navigating Dietary Changes
At the heart of Janelle Brown’s weight loss journey was a significant overhaul of her dietary habits. Initially, Janelle identified specific areas in her diet that needed modification. She began by eliminating processed foods, which were high in unhealthy sugars and fats, replacing them with whole, nutrient-dense options. This shift was not about deprivation but about making mindful choices that fueled her body rather than hindered it. Janelle also found inspiration in new recipes that promoted health without sacrificing flavor. The act of cooking with fresh ingredients became a new hobby for her and allowed her to connect more intimately with her meals.
Furthermore, portion control played an essential role in Janelle’s dietary transformation. She learned to listen to her body’s hunger cues and practiced eating mindfully, which helped her enjoy meals more and stave off overeating. This change was often challenging, especially when confronted with social settings or cravings. Nevertheless, Janelle remained disciplined by establishing meal prep routines that provided her with healthy options throughout the week. By planning her meals, she effectively reduced impulsive, unhealthy eating driven by convenience.
As Janelle continued her journey, she also discovered the joy of discovering new foods that satisfied her taste buds while supporting her health goals. This included experimenting with a variety of cuisines and cooking methods, such as grilling, steaming, and stir-frying. Her exploration of nutritional science helped her understand the importance of macronutrients and micronutrients in her diet. Janelle shared her learnings with her followers, emphasizing that informed choices lead to lasting changes. Thus, her dietary changes were not seen as a temporary solution but a lifestyle adaptation that she could maintain moving forward.
The Importance of Physical Activity
Alongside her dietary adjustments, Janelle Brown recognized the critical role of physical activity in her weight loss journey. At the outset, she began with moderate exercises, focusing on activities that she could enjoy without feeling overwhelmed. This included walking, which served as an excellent starting point for building her endurance. Janelle encouraged others to find activities they enjoyed, reinforcing the belief that exercise should be a source of joy rather than punishment. By incorporating physical activity into her daily routine, she made it a habitual part of her life.
As her fitness level improved, Janelle began experimenting with different forms of exercise, including strength training, yoga, and group fitness classes. Each new endeavor provided her with different benefits and helped her avoid the monotony of a fixed routine. Janelle articulated that finding a community in these classes offered her a sense of connection and accountability. Sharing her workouts on social media not only boosted her motivation but inspired others to join in on similar fitness activities, further cultivating a supportive network.
Over time, exercise transitioned from a task to a passion for Janelle. She reported feeling stronger, both physically and mentally, highlighting improvements in her mood, energy levels, and overall well-being. One significant aspect of her physical activity journey was setting achievable goals. Janelle celebrated milestones, such as running her first 5k or lifting heavier weights in the gym, which reinforced her dedication to her physical health. Overall, Janelle’s commitment to finding enjoyable and sustainable forms of exercise significantly contributed to her remarkable transformation.
Emotional and Mental Resilience
While the physical aspects of Janelle Brown’s journey are often celebrated, her emotional and mental resilience were equally crucial in her transformation. Throughout her weight loss journey, Janelle faced setbacks, moments of self-doubt, and societal pressures that often accompany personal change. Initially, she documented these challenges candidly on her social media platforms, allowing her audience to understand the psychological struggles that could accompany a significant lifestyle change. By doing so, she demonstrated that it was normal to encounter obstacles and that overcoming them was part of the journey.
Janelle’s focus on mental health involved developing coping mechanisms and practicing self-care. She engaged in activities that brought her joy, such as meditation, journaling, and spending time outdoors. By taking time for herself, she cultivated a positive mindset and fostered a sense of self-compassion. Janelle’s journey also highlighted the importance of seeking support, whether through friends, family, or professional counseling. By opening herself up to vulnerability, she created a network that encouraged her and promoted emotional stability.
Sharing her challenges and triumphs became a cornerstone of Janelle’s story. She used her platform to raise awareness about the psychological aspects of weight loss, thereby encouraging her followers to prioritize their mental health alongside physical transformation. Janelle emphasized that emotional resilience was key to lasting change; whenever she faced a setback, she learned to view it as a lesson rather than a failure. In doing so, she fostered a resilient mindset that would not only help her through her weight loss journey but serve her well in other areas of life.
Building a Supportive Community
A pivotal aspect of Janelle Brown’s weight loss journey was the creation of a supportive community. Janelle understood early on that achieving significant lifestyle changes is difficult to do alone. Thus, she sought to surround herself with individuals who shared similar goals or inspired her to push through challenges. Whether through in-person support groups, social media platforms, or fitness classes, Janelle found strength in numbers. Engaging with others who understood her struggles fostered a sense of camaraderie and accountability, both essential components in sustaining motivation.
Janelle became an advocate for community building, often encouraging her followers to connect with like-minded individuals. She initiated challenges, hosted meet-ups, and utilized social media to create space for sharing experiences and tips. This engagement allowed Janelle to build relationships based on trust and mutual support. Additionally, she often highlighted the importance of surrounding oneself with positive influences who uplift and motivate rather than discourage. Her outreach efforts extended beyond her personal journey, transcending into a broader movement that nurtured empowerment and connection.
Ultimately, the bonds Janelle formed through her journey proved invaluable, especially during tough times. When faced with setbacks, she realized the importance of leaning on her support network, turning to those who understood her journey rather than isolating herself. Through her social media presence and open conversations, Janelle fostered a community that inspired others to seek support, thus breaking the stigma often associated with individual struggles. Her story exemplifies that while personal transformation is a solitary endeavor in many aspects, it is often enhanced and supported by a community that stands together in pursuit of wellness.
Reflections and Future Endeavors
Looking back on her extraordinary transformation, Janelle Brown reflected on the lessons learned throughout her journey. Not only did she achieve her goal of losing 100 pounds, but she also developed a deeper understanding of herself, her motivations, and what true wellness means. Janelle acknowledged that weight loss was just one facet of a broader picture that included emotional balance, strong relationships, and a fulfilled life. As she continues to embrace this holistic approach to health, she hopes to inspire others to do the same.
Janelle’s future endeavors include advocating for sustainable health practices, developing platforms where individuals can share their stories and progress, and continuing her journey of self-improvement. She plans to use her experience to educate others about the importance of mental health, nutrition, and community support in achieving personal goals. Janelle envisions creating workshops and online communities focusing on comprehensive wellness, furthering her commitment to making a difference in people’s lives.
In sharing her narrative, Janelle hopes to reach those who struggle with their own journeys, encouraging them to embark on their paths with confidence. Her journey is a reminder that transformation is possible, emphasizing that the support, love, and tenacity needed to create change are available to all. 2024 marks not just a year of weight loss for Janelle but also the beginning of new opportunities and a commitment to inspiring others to embrace health and wellness in all its forms.
Summary of the Journey
Janelle Brown’s weight loss journey in 2024 not only highlights a significant physical transformation but also encapsulates a holistic approach to health and well-being. Her experience serves as an inspiration for many pursuing change in their lives, demonstrating that with determination, support, and a willingness to adapt, profound changes can occur. Janelle’s story is a beacon of hope for anyone feeling stuck or lost in their wellness journey, reminding them that it’s never too late to take charge of their health.
If you’re wondering about the factors contributing to Janelle’s successful transformation, several are noteworthy. A comprehensive dietary change, consistent physical activity, emotional resilience, communal support, and self-reflection all played significant roles in her success. By focusing on these key areas, Janelle was able to create a sustainable lifestyle that worked for her. Drawing upon her journey, she encourages individuals to identify similar factors that may aid in their transformation.
To summarize, Janelle Brown’s weight loss journey of 2024 is not solely about losing pounds; it is an empowering narrative about embracing change, valuing mental health, and creating connections. As she continues to inspire others through her ongoing journey, her experiences illustrate that personal growth is possible in all shapes and forms. Regardless of where you are on your journey, remembering that transformation is a gradual process filled with ups and downs can help build resilience and determination. Embracing this mindset can lead to a more fulfilling and healthier life.

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Submit your nutrition and training questions (https://www.witsandweights.com/question) at witsandweights.com/question to get featured on the show — Discover how a natural sugar called allulose is getting attention for potentially offering similar metabolic benefits as modern weight loss drugs by stimulating GLP-1. Learn the science behind how this unique compound affects blood sugar, appetite, and fat loss through natural pathways. Main Takeaways: • Allulose stimulates GLP-1 more modestly than medications, working with natural body rhythms • Research shows up to 50% reduction in post-meal blood sugar spikes • Practical dosing starts at 5-10g per serving, best taken with meals • May help with transitioning off GLP-1 medications while maintaining results • Shows promise for preserving muscle glycogen during training Timestamps: 4:00 - What is allulose and how it differs from regular sugar 5:17 - Key research findings and real-world uses 8:24 - Practical dosing guidelines and timing considerations 10:05 - Benefits and potential side effects Support the show (https://www.buzzsprout.com/1870546/support) 👩💻 Book a FREE 15-Minute Rapid Nutrition Assessment: https://witsandweights.com/free-call 👥 Join our Facebook community (https://bit.ly/3vyLDqO) for live Q&As & support 👋 Let's connect! Ask a question (https://www.witsandweights.com/question) , get my FREE newsletter (https://witsandweights.com/email) , or find me on Instagram (https://www.instagram.com/witsandweights/) 📱 Try MacroFactor for free (https://www.witsandweights.com/blog/macrofactor) with code WITSANDWEIGHTS. 🏋️♀️ Download Boostcamp for free (https://boostcamp.app/#witsandweights) for evidence-based workout programs 🫙 Get 20% off Legion supplements (https://legionathletics.rfrl.co/nj885) with code WITSpod
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Two new studies suggest the class of weight loss and diabetes drugs that includes Ozempic and Wegovy have the added benefit of protecting against the development of dementia. CBS News medical contributor Dr. Céline Gounder has more. CBS News 24/7 is the premier anchored streaming news service from CBS News and Stations that is available free to everyone with access to the internet and is the destination for breaking news, live events, original reporting and storytelling, and programs from CBS News and Stations' top anchors and correspondents working locally, nationally and around the globe. It is available on more than 30 platforms across mobile, desktop and connected TVs for free, as well as CBSNews.com and Paramount+ and live in 91 countries. Subscribe to the CBS News YouTube channel: https://youtube.com/cbsnews Watch CBS News 24/7: https://cbsnews.com/live/ Download the CBS News app: https://cbsnews.com/mobile/ Follow CBS News on Instagram: https://instagram.com/cbsnews/ Like CBS News on Facebook: https://facebook.com/cbsnews Follow CBS News on X: https://twitter.com/cbsnews Subscribe to our newsletters: https://cbsnews.com/newsletters/ Try Paramount+ free: https://paramountplus.com/?ftag=PPM-05-10aeh8h For video licensing inquiries, contact: [email protected]
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In this video, "Weight Loss Journey | 9 MONTH UPDATE with Measurements: Weigh In Wednesday | Losing 200lbs" I review my ninth month of my weight loss journey and the tactics I used to be successful losing weight, I share my current measurements, weight updates and pictures, and I also do a side by side comparison of last month to this month to when I started. Then, I wrapped up the video by sharing my October Fitness and Weight Loss intentions!! Wish me luck! ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ Wanna jump around? ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ 00:00 The beginning 00:44 Best Month Yet 01:01 Reviewing March Goals and Tactics 07:30 Other Reflections and Chit Chat 09:36 Let’s Weigh In 11:34 Progress pic and Video 15:38 Non-Scale Points of Measure 18:22 April Goals and Tactics 20:32 Sharing some thoughts #weightlossjourney #weighinwednesday #aprillauren ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ Watch next?♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ Starting my weight loss journey | Losing 200 lbs: https://youtu.be/99Nh4_-wLv0 Can I walk a mile with 200 lbs to lose?: https://youtu.be/-1V_Mz5Jdvs How did I become Morbidly Obese: https://youtu.be/4yA0EqNqZUM Weigh In Wednesday Play List: https://www.youtube.com/watch?v=99Nh4_-wLv0&list=PLR1pnoP-75xDhQNQKlJiMRHsx1sB8XXIT ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ A little about me ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ My name is April Lauren and my channel, Wake Up Bright, is where I share the chronicles of my weight loss journey to lose 200 lbs, our adventures and my attempts to make home wherever the Army sends. Essentially, my hope is to wake up a little brighter each day and to do all the little things that ensure I do. Wanna Connect? ♡ Insta: https://www.instagram.com/wakeupbright ♡ Facebook: https://www.facebook.com/loveaprillauren ♡ TikTok: http://www.tiktok.com/@april.lauren ♡ Blog: http://www.wakeupbright.com ♡ Email me: [email protected] (Personal) Wanna work with me? Email: [email protected] ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ Common Q's♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ ♡ What I'm wearing?! If it's athetic gear, it is probably fabletics: https://fabletics.fjbu.net/loveaprillauren (otherwise, I'll provide links!) What kind of Camera do I use? Go Pro Hero 7: https://amzn.to/2D66nhf Canon G7xII: https://amzn.to/2S1265O Wanna know more about my gym watch my gym tour: https://youtu.be/5ms3_ZwR7pU. (The description also has links to all equipment) Should you start a YouTube Channel? https://youtu.be/pMDUWWRSRjs Wanna do Yoga with me? https://www.youtube.com/channel/UCSlXMj3JZ8mLJqX_o9hpBcw/ More about my pups? https://www.youtube.com/watch?v=vqTIMpZjwIw DISCLAIMER: Links included in this description might be affiliate links. weight loss journey, weigh in Wednesday, one month weight loss progress, how much weight can I lose in a month, starting my weight loss journey ,losing 200 lbs, plan for success, weight loss, how to lose weight, slow and steady weight loss, how to lose weight the healthy way, mental strength, weight loss motivation, watch me shrink, lose weight with me, fat to fit, how to get fit, how to lose fat, how to lose fat when you are overweight, how to lose weight when you're obese
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What is GLP-1 and how does it affect our bodies? Dr. Fab Sagebin explains how yerba mate releases GLP-1 and how GLP-1 helps with weight loss.
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Crossfire gummies are a groundbreaking supplement for active people on targeted ketogenic diets. They maintain ketosis and allow athletic performance improvement that demands their use as they provide the body with an ideal nutrient level.
Advantages of Crossfire Gummies
One of the main benefits of these gummies is that they are designed to help people following a keto diet. These special gummies assist your body to stay in ketosis, which is important for burning fat and gives you energy throughout physical activities. By including Crossfire Gummies in your daily schedule, you can get into a state of ketosis more effectively while enhancing your performance even further.
Crossfire Gummies also contain vital vitamins and minerals that are rarely found in a well-formulated ketogenic diet. These nutrients play an essential role in maintaining overall wellness hence ensuring optimal performance of our bodies. With Crossfire Gummies, one can be able to feed their bodies with all the necessary nutrients required for it to perform at its best.
How Crossfire Gummies Work
They accelerate the process of entering ketosis and improve physical activity capacity by supplying the body with necessary nutritional components needed to support such processes. This product is made from high-quality ingredients chosen specifically for those who engage in ketogenic lifestyle; thus, they make a perfect addition to your regular supplements intake. Taking this dietary supplement on a daily basis allows you making sure your organism has everything it needs while keeping up with keto.
One key ingredient used in making cross fire gummy bears is MCT oil which is known for promoting ketosis as well as boosting energy levels. Medium-chain triglycerides (MCTs) are fat molecules that are easily absorbed by the body and converted into substrates called ketones which become fuel sources during times when carbs are restricted.Combining MCT oil with other components in this product allows it to enhance user’s results and boost individual’s performance.
Why Choose Crossfire Gummies?
There are many reasons why one should consider Crossfire Gummies as their go-to supplement for targeted ketogenic support. These sweeties are manufactured from premium ingredients chosen specifically for people who follow the keto lifestyle, hence ensuring that you will get most out of your dieting and workout programs. When using Crossfire Gummies, you should be confident that your body is provided with all the necessary support to live on.
In addition, Crossfire Gummies are very easy and convenient to incorporate into a daily schedule of an individual. By taking only few gummies every day it is possible to enjoy benefits of a targeted ketogenic support even when one is on the move. Whether you want energy for gym activities like running or just something to pick you up quickly, Crossfire Gummies can serve the purpose properly in case you have a tight schedule.
Maximizing Your Results with Crossfire Gummies
If users are seeking to achieve maximum results through consuming cross fire gummy bears, they need to combine it with good eating habits and regular exercise routine. As a result, these gummy sweets are created in such a way as to fit into ketogenic diets; therefore, one needs to be consistent while keeping in mind what he/she eats and does most of the time. Also, hydration and enough rest should not be overlooked at this point since they facilitate acclimatization of user’s body system onto ketosis.GenerationType
Hey, listen to your body and adjust your routine as needed. And if you have any questions or concerns on how to include Crossfire Gummies in your lifestyle, consult a healthcare provider or nutritionist. You can attain health and fitness objectives with the help of Crossfire Gummies once encouragingly supported.
Are you ready to take your performance to the next level with Crossfire Gummies? Order them today and enjoy some benefits of targeted keto support for athletic individuals!
Summary & FAQs
Can I take Crossfire Gummies if I am not on a ketogenic diet?
Though made for the ketogenic dieters, they generally work well for anyone trying to build their overall health status. This rich nutrient formula can offer vitamins and minerals that are most often missed from diets making it into an excellent daily addition like gummy.
How many Crossfire Gummies do I need to take per day?
Depending on your needs and activity levels, 2-4 gummies are recommended per day by Crossfire Gummies. Also, consult medical guidance in case one is unsure of what dosage they should choose after following the package instructions.
What are the side effects of taking Crossfire Gummies?
Usually, high-quality ingredients define these products so that they can be tolerated by everybody. Nonetheless, just as with other supplements, there is need for adherence to dosage recommendations and recognizing individual signs. Stop use if unusual symptoms or side effects occur and see doctor.
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