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Partial or biased agonism to improve GLP-1 receptor agonist properties by Ben Jones, Clinical Senior Lecturer Imperial College London I will discuss our work aiming to understand whether the therapeutic properties and side effect profile of GLP-1R agonism can be improved by refining intracellular signalling properties. Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focused on the translational pharmacology of G protein coupled receptors in metabolic disease. He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor. After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship. Current work aims to establish the mechanism of action of “biased” incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity. https://thelongevityforum.com

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The Blood Type Diet (AKA Eat Right 4 Your Type) claims there are certain foods and lifestyles better suited for different blood types. Is there any merit to this? And why do we have different types of blood in the first place? Read More: "Blood Type Diet: What You Need to Know" http://health.howstuffworks.com/wellness/diet-fitness/diets/blood-type-diet1.htm "Let's start with the basics -- your blood type. If you're unaware of this important factor, you'll need to figure it out because it'll dictate your food plan." "Really? Blood Type Influences Heart Disease Risk" http://well.blogs.nytimes.com/2012/08/20/really-blood-type-influences-heart-disease-risk/ "Knowing your blood type is important if you need a blood transfusion. But can it also tell you something about your risk of heart disease?" "What Your Blood Type Reveals About Your Health" http://health.yahoo.net/experts/dayinhealth/what-your-blood-type-reveals-about-your-health "A new Harvard study published in Arteriosclerosis, Thrombosis, and Vascular Biology shows that your blood type can actually predict your risk for heart disease." "Weight Loss Help For Different Blood Types" http://www.livestrong.com/article/341601-weight-loss-help-for-different-blood-types/ "Choosing what foods to eat and what exercises to do based on blood type is a popular weight-loss technique." "Human blood types have deep evolutionary roots" http://www.sciencenews.org/view/generic/id/345987/description/Human_blood_types_have_deep_evolutionary_roots "Chimps, gibbons and other primates are not just humans' evolutionary cousins; a new analysis suggests they are also our blood brothers." "The Eat Right for Your Blood Type Diet" http://www.webmd.com/diet/eat-right-for-your-type?page=2 "The Eat Right for Your Type diet encourages people to eat certain foods and avoid others based on their blood type -- A, B, AB, or O." "Why do people have different blood types?" http://www.scientificamerican.com/article.cfm?id=why-do-people-have-differ "The types of proteins, glycoproteins and glycolipids found (or expressed) on the surface of red blood cells define blood types." DNews is a show about the science of everyday life. We post two new videos every day of the week. Watch More http://www.youtube.com/dnewschannel Stop Bleeding Instantly! ►►►► http://bit.ly/241z8j7 Subscribe http://www.youtube.com/channel/UCzWQYUVCpZqtN93H8RR44Qw?sub_confirmation=1 DNews Twitter https://twitter.com/dnews Anthony Carboni Twitter: https://twitter.com/acarboni Laci Green Twitter https://twitter.com/gogreen18 Trace Dominguez Twitter https://twitter.com/trace501 DNews Facebook http://www.facebook.com/DNews DNews Google+ https://plus.google.com/u/0/106194964544004197170/posts DNews Website http://discoverynews.com/