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Revolutionizing Obesity Treatment: The Potential of Orforglipron In this episode of Downsized, host Christopher Durham discusses a groundbreaking development in the treatment of obesity—a once-daily pill called orforglipron from Eli Lilly. Unlike traditional GLP-1 medications that require injections, orforglipron is an oral small molecule GLP-1 receptor agonist, making it more accessible and convenient. The drug recently achieved a milestone in a phase three clinical trial, demonstrating significant reductions in A1C levels and weight loss among participants with type 2 diabetes. Christopher highlights the potential of orforglipron to drastically lower costs and overcome barriers such as fear of needles, thereby opening up obesity treatment to millions more people. As Eli Lilly prepares to bring this medication to market, Christopher advocates for affordable pricing and wide accessibility, positioning orforglipron as a game-changer in the global battle against obesity. Tune in to learn more about this revolutionary drug and its implications for the future of weight management. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store As an Amazon Associate, I earn from qualifying purchases. Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Bold Claims 00:25 Meet the Hosts 01:28 The Revolutionary Pill: Orforglipron 01:56 Clinical Trial Results 04:08 Impact on Diabetes and Obesity 04:58 The Convenience and Accessibility of Orforglipron 05:32 Pricing and Market Strategy 07:52 Future of Obesity Treatment 08:53 Call to Action and Conclusion

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Subscribe to The Doctors: http://bit.ly/SubscribeTheDrs LIKE us on Facebook: http://bit.ly/FacebookTheDoctors Follow us on Twitter: http://bit.ly/TheDrsTwitter Follow us on Pinterest: http://bit.ly/PinterestTheDrs Stay up to date on breaking health headlines! Hear shocking details on a spiteful letter targeting the mother of autistic children! Then, why a father with stage 4 cancer was denied a potentially life-saving treatment! Plus, a former show guest reveals how she dropped 140 pounds in just one year!

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In this episode, Mike Fave explores the critical importance of preserving lean muscle mass during weight loss, especially when using caloric restriction or fasting. He explains how lean muscle is the body’s primary source of metabolically active tissue and why losing it can lower your metabolic rate, making it harder to maintain weight loss. Learn the science behind fat mass versus fat-free mass, the impact of aging on muscle loss, and how to set up a fat-loss diet without sacrificing muscle. Discover the importance of adequate protein intake, resistance training, and strategic tracking to optimize your weight loss journey. 🔹 Looking for Help Losing Body Fat Without Losing Muscle? ✅ Download The Nutrition Blueprint → https://mikefave.com/the-nutrition-blueprint/ ✅ Work With Me → https://mikefave.com/work-with-me/ 🔹Where to Find Me: ✅ Website: https://mikefave.com/ ✅ Twitter: https://x.com/MikeFaveScience/ ✅ Instagram: https://www.instagram.com/mikefavescience/ ✅ YouTube: https://www.youtube.com/@MikeFaveScience/videos 🔹 Timestamps: 0:00 - Introduction: The Risk of Losing Lean Muscle in Weight Loss 0:14 - Importance of Maintaining Lean Muscle Mass 0:30 - Role of Metabolically Active Tissue in Weight Loss 0:38 - Impact of Caloric Restriction on Metabolic Rate 1:17 - Fat Mass vs. Fat-Free Mass: Energy Usage Explained 2:04 - Total Daily Energy Expenditure Breakdown 2:37 - Metabolically Active Organs and Their Energy Consumption 3:40 - Importance of Maintaining Fat-Free Mass for Metabolism 4:45 - Muscle Mass and Aging: Impact on Mortality and Health 5:52 - Case Study: Muscle Mass Changes from Young to Old Age 7:13 - Consequences of Muscle and Bone Loss in Aging 8:11 - Risks of Severe Caloric Restriction 10:51 - Importance of Micronutrients in Caloric Restriction 12:09 - Protein Intake: Key to Preserving Lean Muscle Mass 12:52 - Role of Resistance Training in Preventing Muscle Loss 13:45 - Importance of Adequate Protein and Resistance Training 14:14 - Risks of Yo-Yo Dieting and Loss of Lean Muscle Mass 15:28 - Strategies for Tracking Progress and Adjusting Diet 16:52 - Triangulating Symptoms, Weight, and Lean Body Mass 17:00 - Conclusion & Call to Action: Preserve Muscle While Losing Fat Sources: https://www.mdpi.com/2072-6643/10/4/423 https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1363181/full https://pmc.ncbi.nlm.nih.gov/articles/PMC9036397/#R82 https://www.ncbi.nlm.nih.gov/books/NBK591031/# 🔹 Disclaimer: This video is for informational purposes only and does not constitute medical, nursing, or healthcare advice, nor does it establish a doctor-patient relationship. The use of this information is at the user’s own risk and is not a substitute for professional medical advice, diagnosis, or treatment. Users should not delay seeking medical advice and should consult a qualified healthcare provider before making any dietary, lifestyle, or medical changes. The views expressed are for educational discussion and do not constitute medical treatment or diagnosis.

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