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incretin effect| incretin effect glp-1| incretin effect explained| incretin effect in diabetes| incretin hormones| incretin based therapy of diabetes ▪ Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β cells. The major mechanism of metabolism of the incretins is cleavage by dipeptidyl peptidase 4 (DPP4), an enzyme that is ubiquitously expressed, including in endothelial cells. ▪ Two pharmacological approaches have been taken to enhance the incretin effect in type 2 diabetes. One approach is to administer GLP-1 'analogues' (GLP-1 receptor agonists) that are resistant to cleavage by DPP4. The other approach is to inhibit DPP4 activity. This effectively increases the half-life and therefore the circulating concentrations of the incretins. ▪ In summary, Ingested glucose causes secretion of incretins from GI tract. These ingredients then increase insulin secretion from the pancreas. Anti-diabetic drugs targeting this mechanism are glp1 analogues and dpp4 inhibitors. And in this way, by increasing insulin secretion, the incretins lower blood glucose. Chapters: 0:00 - Insulin Secretion Mechanism 0:42 - Incretin Effect 1:10 - Incretin Hormones 1:26 - Glucagon-like peptide-1 (GLP-1) Hormone 2:19 - Problem in Diabetes 2:35 - GLP-1 analogues and DPP-4 inhibitors 3:24 - Summary of Incretin Effect incretin hormones, incretin effect, incretin effect glp-1, incretin effect explained, incretin effect in diabetes, insulin, diabetes, glucagon like peptide 1, incretin based therapy of diabetes, incretin pathway, incretin and glp-1, glp 1 analogs, dpp4 inhibitors, sitagliptin, vildagliptin, exenatide, liraglutide, oral antidiabetic drugs, mechanism of insulin secretion, insulin secretion, insulin physiology, insulin pharmacology, diabetes mellitus, medicine, pharmacyd by asim ☕ Buy Me A Coffee: https://www.buymeacoffee.com/pharmacyd 💡 Facebook: https://web.facebook.com/pharmacyd0929 For any Queries and Suggestions Email on: [email protected] Disclaimer: "Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition." A Famous Quote is: "What We Know is a Drop. What We Don't Know is an Ocean".
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