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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. Purchase a license to download a non-watermarked copy of this video on AlilaMedicalMedia(dot)com ©Alila Medical Media. All rights reserved. Voice by: Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting. Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect. Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron. Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users. At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors. Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death. Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.

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Alex avoided food after workouts and saw no results. Dr. Nony explains how eating smart—even at night—can transform your fat loss and recovery. #motivation FitnessMistakes #LateNightProtein #DrNony #MuscleRecovery #SmartEating #FatLossTips #PowerLab #NutritionCoach #InternalMedicineDoc

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In this episode, we delve into the recent strategic moves I've made in my portfolio, which may have caught some by surprise but are rooted in my reading of evolving market dynamics. Here’s a breakdown of the latest decisions: exited positions in Costco with a 17% gain, Empire at break-even, Walmart with a 17.5% gain, Target at a -2% loss, and iShares Pharma at a loss of 3.6%. These are substantial moves that weren’t initially on my agenda. It’s important to note that these decisions weren’t based on the underlying fundamentals or valuations of these companies – which I continue to appreciate. The catalyst was rather a growing sense of a short-term negative game-changer moment on the horizon. I've previously discussed the potential impact of Ozempic, and more broadly, the GLP-1 family of drugs, on sectors beyond healthcare due to their potential in reducing obesity and promoting weight loss. This thread pulls at the fabric of various industries: The potential societal disruption is enormous, and while the world buzzes about AI and ChatGPT, this healthcare evolution could be a parallel narrative growing in significance. Reflecting on my portfolio, the decent returns already achieved were near my threshold of satisfaction. The decision to secure these profits and transition to lower risk, chunky yield options seemed a prudent move amidst the growing narrative. The key takeaway here is that admiring a company doesn't always equate to liking its stock at a given moment. While I have a positive outlook on COST and WMT, the short-term negative sentiment driving down stock values led me to bank the profits and await a more opportune entry point. Concerns loom around the long-term impacts of these drugs, creating a potential false sense of security leading to overeating, and the unknown side effects that could emerge over time. The play moving forward hinges on the momentum GLP-1 drugs gain. If this narrative unfolds akin to how AI captured market attention, it could depress stock values in the short term. This scenario presents an opportunity to re-enter at a more favorable price point. If it doesn’t pan out, the gains locked in provide a cushion to strategize for another day, especially with external market pressures like high valuation, sustained high rates, inflation, a potential hard landing, and geopolitical tensions looming large.

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“Confidence changes everything! With the help of SheMed’s personalised weight loss programme, I’ve not only transformed my body but also regained my self-assurance and energy. Through clinically guided GLP-1 medication, lifestyle support, and the SheMed app, I’ve taken control of my health and reached goals I never thought possible. If you’re ready to prioritise YOU, visit our website to learn more: https://www.shemed.co.uk/ #SheMedSuccess #WeightLossJourney #ConfidenceRestored #GLP1Medications”

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Fuel Your Keto Goals. Step into a world where indulgence meets intention with the Salted Toasted Coconut KetoBar. This KetoBar is crafted for those who embrace a ketogenic, Paleo, or plant-based lifestyle. With its 85% cacao content and blend of toasted coconut and Himalayan pink salt, this KetoBar is more than a chocolate snack — it supports a restricted ketogenic diet. KetoBars are packed with healthy fats by incorporating additional cocoa butter. A 40g serving delivers 18% of the recommended daily total fat intake and includes omega-3 and omega-6 fatty acids.. With 0 cholesterol, 0 sugar, 0 trans fat, and 7g carbs per square, KetoBars enable you to stay on track without sacrificing flavor or enjoyment. At the heart of this KetoBar is intense, sugar-free dark chocolate. It is flavored with coconut and Himalayan pink salt. Made with "Cultivate Belter Cacao" and modestly sweetened with a blend of stevia, inulin, and erythritol, each square delivers a bold chocolaty flavor. Coconut contributes fiber and saturated fat MCTs which are used by the body to produce energy. The salt gets its pink color from minerals and trace elements and was formed millions of years ago from the evaporation of ancient seas. #keto #ketodiet #ketodessert #weightloss

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Missing medication doses during festive seasons can lead to serious conditions like pancreatitis. Learn to recognize symptoms such as severe abdominal pain, nausea, jaundice, and more. Discover when to seek urgent medical attention to stay safe. 00:00 Understanding the Risks of Missing Medication Doses 00:12 Recognizing the Symptoms of Pancreatitis 00:45 When to Seek Urgent Medical Attention

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If you would like to fix the *one BIG thing* interfering with your weight loss goals, I can help you with that. To schedule a consult call: https://calendly.com/weightmedicinemd I'm a doctor and a life coach, and I help people with their weight. Fix The ONE BIG THING: https://youtu.be/qCJ5xSswJeo?si=tJsIGTFRZm6Zbwtu If you are confused about your weight, if you have questions about weight medicine, and if you want fact-based answers to your weight questions, you are in the right place. 0:00 Introduction & Consult Week Announcement 2:03 Weightlifting vs Cardio on GLP-1s 4:40 Why Am I Not Losing Weight on GLP-1 in Menopause? 10:35 How Many Calories Are Too Few on GLP-1s? 12:29 How Long Does It Take to Lose 50 Pounds on GLP-1s? 15:46 Closing & How to Work with Me Menopause video: https://youtu.be/KzXdt5mzr_8?si=iNC4jkNiWhOJpvH9 Not Affiliate Links, Just a Fan: Candle: @kristinabraly www.aembr.co The information in this video is intended to serve as educational information and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor. There is no patient-doctor relationship created in this video.

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