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View show notes here: https://bit.ly/4exzjNe Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ In this “Ask Me Anything” (AMA) episode, Peter dives back into the increasingly popular topic of GLP-1 agonists, such as Ozempic & Mounjaro, which have garnered widespread attention for their ability to promote weight loss. Peter covers the latest findings in this rapidly evolving landscape, including new insights into their long-term efficacy, side effects, & what happens when the drug is discontinued. Peter also explores their impact on body composition & how resistance training interacts with these treatments. Additionally, he compares different GLP-1 receptor agonists & discusses promising new drugs in the pipeline. Finally, Peter addresses questions about the role of compounding pharmacies in the GLP-1 agonist market, compares oral vs. injectable options, & provides key considerations for anyone deciding whether to use a GLP-1 agonist for weight loss. We discuss: 00:09 - The rapidly evolving landscape of GLP-1 agonists 5:14 - The mechanism of GLP-1 agonists, origin as diabetes treatments, & how they evolved into weight-loss drugs 09:08 - Overview of new data & open questions related to the benefits & risks of GLP-1 agonists 16:19 - New insights into the long-term safety of GLP-1 agonists & side effects In the full episode, we also discuss: The long-term efficacy of GLP-1 agonists, financial barriers, & more; The mechanisms behind GLP-1 agonists' ability to promote weight loss; New data on body weight changes after discontinuing the drug; Effects of GLP-1 agonists on lean mass & body composition, & the role of protein & resistance training in preserving muscle; Semaglutide vs. tirzepatide; How compounding pharmacies affect availability of GLP-1 drugs & the available formulations; How oral formulations of GLP-1 drugs compare to injectable formulations; How sublingual (under tongue) formulations of GLP-1 drugs compare to injectable formulations; Guidance for using compounding pharmacies to purchase GLP-1 agonists; Data on retatrutide—a promising new triple receptor agonist in the pipeline; Can GLP-1 agonists be beneficial for sleep apnea & immune function?; Potential neuroprotective benefits of GLP-1 agonists: impact on dementia risk; Exploring why GLP-1 agonists may reduce the risk of cancer, kidney disease, & cardiovascular disease; How GLP-1 agonists might boost fertility in women; Early indications that GLP-1 agonists may help treat substance abuse disorders; Potential health risks of GLP-1 agonists: addressing thyroid cancer concerns & the unknowns due to lack of data; Examining the potential link between GLP-1 agonists & increased depression or suicidal ideation; Major remaining questions: the effects of cyclic use, rebound appetite, impact on adolescents' development, & more; Key considerations when deciding whether to use a GLP-1 agonist for weight loss; -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only & does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information & the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, & they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures & the companies I invest in or advise, please visit my website where I keep an up-to-date & active list of such companies. For a full list of our registered & unregistered trademarks, trade names, & service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/

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Today we're going to learn about Samantha and her weight loss journey on Phentermine. Phentermine has been shown to be effective in promoting weight loss in overweight and obese individuals, it is important to note that a healthy diet and exercise routine are crucial components in achieving long-term weight loss and overall health. Phentermine has been used by many people, including celebrities, to help them lose weight and achieve their weight loss goals. However, it should be noted that phentermine is not a magic pill and should always be used in conjunction with a healthy diet and exercise routine. There have been numerous scientific studies that have proven the effectiveness of phentermine for weight loss, but it should only be used for a limited period of time and under the supervision of a doctor. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and healthy habits, is crucial for long-term weight loss and overall health. _______________________________Welcome to The Good Health Gorilla! ___________________________ Where we share fun facts or myths on several topics such as nutrition, abs training, functional fitness, how to boost your immune system, and general health and well being tips! Subscribe today to stay on track with your fitness goals: https://bit.ly/2YWzHA7 ➤Intermittent Diet Fasting Program [Affiliate Link]: https://1eb03i2df8tyqvs7lxj0ubu-n2.hop.clickbank.net/ ➤Speed Keto Program [Affiliate Link]: https://1b748g2jj6j-squ933tpiz4r0a.hop.clickbank.net/ ➤20 Minute Body Program [Affiliate Link] : https://77ae1d-8k2o-ooqv4hr9rp1t51.hop.clickbank.net/ ____________________Scientific Studies___________________________ Apovian, C. M., Aronne, L. J., Bessesen, D. H., McDonnell, M. E., Murad, M. H., Pagotto, U., Ryan, D. H., Still, C. D., & Endocrine Society (2015). Pharmacological management of obesity: an endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism, 100(2), 342–362. https://doi.org/10.1210/jc.2014-3415 Craddock D. (1976). Anorectic drugs: use in general practice. Drugs, 11(5), 378–393. https://doi.org/10.2165/00003495-197611050-00002 Davidson, K., Van De Walle, G. (2021). Does Phentermine Work for Weight Loss? A Diet Pill Reviewed. Healthline. Retrieved from https://www.healthline.com/nutrition/phentermine-weight-loss Lewis, K. H., Fischer, H., Ard, J., Barton, L., Bessesen, D. H., Daley, M. F., Desai, J., Fitzpatrick, S. L., Horberg, M., Koebnick, C., Oshiro, C., Yamamoto, A., Young, D. R., & Arterburn, D. E. (2019). Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort. Obesity (Silver Spring, Md.), 27(4), 591–602. https://doi.org/10.1002/oby.22430 Shah, M. (n.d.). Is phentermine a good choice for weight loss?. Mayo Clinic. Retrieved from https://www.mayoclinic.org/healthy-lifestyle/weight-loss/expert-answers/phentermine/faq-20057940 Srivastava, G., & Apovian, C. M. (2018). Current pharmacotherapy for obesity. Nature reviews. Endocrinology, 14(1), 12–24. https://doi.org/10.1038/nrendo.2017.122 The University of Texas at Asutin. (n.d.). Phentermine Alternatives – Best Natural Substitutes for Prescription weight loss medication and Phentermine Pills. Retrieved from https://sites.utexas.edu/leverage/2022/12/13/phentermine-alternatives-best-natural-substitutes-for-prescription-weight-loss-medication-and-phentermine-pills/ WebMD. (n.d.). Phentermine HCL - Uses, Side Effects, and More. Retrieved from https://www.webmd.com/drugs/2/drug-4151/phentermine-oral/details Yanovski, S. Z., & Yanovski, J. A. (2014). Long-term drug treatment for obesity: a systematic and clinical review. JAMA, 311(1), 74–86. https://doi.org/10.1001/jama.2013.281361 ➔ Check Out These Popular Videos ► How To Stop Binge and Emotional Eating | No More Binge & Emotional Eating https://youtu.be/EsFvvHvckms ► How Food Can Improve Your Mental Health | Eat Right To Feel Right https://youtu.be/8PeGk8BeVrY ➔ Don't Forget To SUBSCRIBE! Stay Connected With The Good Health Gorilla https://www.youtube.com/channel/UCUkibT56rY9tGC0hlsY_Icg/?sub_confirmation=1 #phentermine #weightloss #LoseBellyFat #goodhealthgorilla DISCLAIMER: This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Good Health Gorilla is not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or affiliate site.

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