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主要討論點與發現包括：整體減重效果與組成：研究證實GLP-1藥物能有效減重。相較於安慰劑組，使用GLP-1藥物的受試者平均多減輕約3.55公斤體重，其中脂肪量平均減少約2.95公斤。然而，瘦體組織（主要是肌肉）也平均減少了0.86公斤。肌肉流失的比例與影響：肌肉流失的0.86公斤約佔總減重量的四分之一（約25%）。雖然研究顯示肌肉量的減少比例大致上與整體體重下降的比例相當，並非藥物「專門」消耗肌肉，但絕對重量的減少仍是實際存在的影響。肌肉流失可能影響基礎代謝率，增加體重回彈的風險，並可能影響體力與日常活動功能。這對於年長者、原有肌少症風險或肌少性肥胖（體脂高但肌肉量少）的族群尤其需要留意，因為糖尿病和肥胖本身就是肌少症的風險因子。不同藥物與劑量的比較：研究利用網路統合分析方法，比較了不同GLP-1藥物和劑量的效果。結果顯示，減重和減脂效果最強的藥物包括每週施打15mg的Tirzepatide（相較安慰劑平均多減約11公斤）以及每週施打2.4mg的Semaglutide。然而，這些減重效果最強的藥物（包括Tirzepatide 15mg、Semaglutide 2.4mg和Semaglutide 1.0mg）同時也是導致瘦體組織（肌肉）減少最明顯的。效果與肌肉保留的平衡：研究的重疊排序分析發現，Liraglutide（特別是每日1.8mg或每週3.0mg的劑量）在減重效果與保留瘦體組織（肌肉）之間可能取得較好的平衡。相較於安慰劑，Liraglutide在統計上未顯示導致顯著的肌肉量減少，同時仍能達到不錯的減重效果。減重品質的重要性：會議強調，使用GLP-1藥物減重不應只關注體重計上的數字，更應關注減重的「品質」，即盡量減少脂肪並保留肌肉。這對於長期維持代謝率、身體功能及預防體重反彈至關重要。肌肉量與功能的區別：會議最後提出一個未完全解決的問題：肌肉量的減少是否直接等同於肌肉功能的下降？研究主要測量肌肉量，但功能性數據較少。有小型研究（如Slim Liver研究）顯示，即使肌肉體積減少，功能可能仍能維持。這引導出未來研究方向：結合運動或高蛋白飲食是否能幫助在使用藥物時更好地保留肌肉功能。

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Weight Watchers and the ketogenic diet are two of the most popular diets in the world, with millions of followers who swear by their effectiveness. Weight Watchers is a program that focuses on counting points to track food intake, while the ketogenic diet encourages followers to eat high-fat, low-carb foods to enter a state of ketosis. Both diets have their own set of guidelines and rules, but what happens when you combine the two? Enter Weight Watchers Keto Gummies, a new product that aims to bring the best of both worlds together.

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