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Full interview: http://sigmanutrition.com/episode65/ Episode 65: Lyle McDonald is on the show to discuss the metabolic adaptations that take place when dieting, the connection between cortisol and water retention and the role of leptin in dieting and weight regain. In this episode we discuss: Metabolic adaptations to dieting Low calories + lots of cardio = no weight loss??? What’s actually going on The connection between cortisol and water retention The central role of leptin in bodyweight regulation Leptin resistance Effects of lowered calories on leptin Gender differences in hormonal responses to dieting Carbohydrate refeeds: Can they mitigate leptin drops? Which of Lyle’s books should YOU read?

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The makers of the popular weight loss drug Wegovy say new data, from one of their longest medical trials to date, shows the drug has sustained benefits. Novo Nordisk says patients taking the drug maintained an average 10 per cent weight loss after four years on the treatment. After years of persistent shortages, the drug finally became available to Canadians as of last week, despite being greenlit since 2021. Global health reporter Katherine Ward has more on the results of the trial. For more info, please go to https://globalnews.ca/news/10476494/wegovy-drug-canada-weight-loss-drug/ Subscribe to Global News Channel HERE: http://bit.ly/20fcXDc Like Global News on Facebook HERE: http://bit.ly/255GMJQ Follow Global News on X HERE: http://bit.ly/1Toz8mt Follow Global News on Instagram HERE: https://bit.ly/2QZaZIB #GlobalNews #wegovy #wegovyweightloss

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6 Reasons You Are Not Losing Weight Even Though You Are In A Calorie Deficit

When it comes to the “best cardio workout” or the “best cardio routine”, there tends to be a lot of confusion. And although cardio is by no means necessary for fat loss given that you’re eating at a calorie deficit through your diet, it can definitely help speed up the process and make things easier in a sense. Now in terms of what is the best form of cardio for fat burning or the best fat burning exercises, you have a lot of potential options. However, one thing you need to prioritize is PREVENTING muscle loss even if your main goal is fat loss – this is what enables your physique to dramatically improve as you lose weight. What’s the best form of cardio to do this? Well, HIIT cardio workouts are definitely something you should include mainly because of its potential muscle sparing properties. HIIT training can be done in a fraction of a time as LISS and is a great cardio workout to burn fat. However, HIIT is very demanding on the body which is why you should ALSO combine it with a few LISS (low intensity steady state cardio) sessions per week as well. This helps mitigate any potential muscle recovery issues you’d have with HIIT. In this video, I’ll show you how to combine the two in order to set up the best fat burning cardio workout routine! LINK TO MY INSTAGRAM/FACEBOOK: https://www.instagram.com/jeremyethier/ https://www.facebook.com/Jeremyethierfit/ LINK TO WRITTEN ARTICLE (BUILTWITHSCIENCE.COM): https://builtwithscience.com/cardio-workouts/ MY PROGRAMS: https://builtwithscience.com/bws-free-fitness-quiz/gender?utm_source=Youtube&utm_medium=Video&utm_content=Description%20box&utm_campaign=Cardio%20routine%20to%20lose%20fat%20Jul%201%2F2018 STUDIES: Cardio and muscle loss: https://www.ncbi.nlm.nih.gov/pubmed/22002517 HIIT vs LISS benefits: https://journals.lww.com/acsm-essr/Fulltext/2009/07000/High_Intensity_Interval_Training_to_Maximize.6.aspx https://www.ncbi.nlm.nih.gov/pubmed/26243014/ HIIT cycling benefits: https://www.ncbi.nlm.nih.gov/pubmed/24055861 , https://www.ncbi.nlm.nih.gov/pubmed/19387377 When to perform cardio: https://www.ncbi.nlm.nih.gov/pubmed/27658232 MUSIC: https://soundcloud.com/lakeyinspired Song 1: Lakey Inspired – Feeling Good Song 2: Lakey inspired – Better days

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When it comes to weight loss medications, Tirzepatide and Semaglutide have been gaining popularity for their effectiveness in aiding weight loss in patients with obesity. Both medications belong to the class of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and have shown promising results in clinical trials. However, there are differences in their dosage protocols and administration that may influence the choice between the two drugs for weight loss treatment.

Tirzepatide Dosage Protocol

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist that has shown superior weight loss efficacy compared to Semaglutide in clinical trials. The recommended starting dose of Tirzepatide for weight loss is 5 mg once weekly, with the option to increase to 10 mg once weekly after four weeks if tolerated. The maximum dose of Tirzepatide for weight loss is 15 mg once weekly.

Semaglutide Dosage Protocol

Semaglutide is a well-established GLP-1 receptor agonist that has been approved for the treatment of obesity. The recommended starting dose of Semaglutide for weight loss is 0.25 mg once weekly, with a gradual dose escalation to 1 mg once weekly over a period of four weeks. The maximum dose of Semaglutide for weight loss is 2.4 mg once weekly.

Comparing Efficacy

Several clinical trials have compared the efficacy of Tirzepatide and Semaglutide for weight loss. One study found that Tirzepatide resulted in greater weight loss compared to Semaglutide, with patients achieving an average weight loss of 14.9% with Tirzepatide versus 10.4% with Semaglutide after 52 weeks of treatment. Another study reported that Tirzepatide was more effective in reducing HbA1c levels and improving cardiovascular risk factors compared to Semaglutide.





Adverse Effects

Both Tirzepatide and Semaglutide are generally well-tolerated, but they can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. In clinical trials, the most common side effects reported with Tirzepatide were gastrointestinal-related, while Semaglutide was also associated with injection site reactions. Patients should be monitored closely for these side effects and managed accordingly to ensure treatment adherence.

Patient Considerations

When choosing between Tirzepatide and Semaglutide for weight loss, healthcare providers should consider the patient’s individual preferences, comorbidities, and cost of treatment. Some patients may prefer the convenience of once-weekly injections with Tirzepatide, while others may prefer the established efficacy of Semaglutide. It is important to discuss the options with patients and tailor the treatment plan to their specific needs and goals.

Conclusion

In conclusion, both Tirzepatide and Semaglutide are effective options for weight loss in patients with obesity. The choice between the two drugs will depend on the individual patient’s preferences, tolerability, and treatment goals. Healthcare providers should consider the dosage protocols, efficacy, adverse effects, and patient considerations when recommending either Tirzepatide or Semaglutide for weight loss.

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She lost 20kg on a popular weight loss drug... but what she really lost may never come back. 🧠💪 Find out why muscle and bone loss after 60 is a risk doctors rarely mention. 👉 Watch to understand the true cost of fast weight loss. Watch full video: The Hidden DANGERS of Weight Loss Injections They DON'T Tell You! https://www.youtube.com/watch?v=ZwJJuy_IQYU #weightloss #ozempic #wegovy #muscleloss #biohacking #healthfacts #medicalshorts

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Buy Dihydroberberine https://geni.us/zG8aYoA Buy Berberine https://geni.us/BeppQI Disclosure: I participate in the Amazon Services LLC Associates Program, an affiliate advertising program. As an Amazon Associate, I earn from qualifying purchases made through links on this channel. Disclaimer: This podcast is for informational and educational purposes only and does not constitute medical advice. The content is based on publicly available research, including information accessed through Notebook LM from the U.S. National Library of Medicine (PubMed), and BMI Doctors. This information should not be used to diagnose, treat, cure, or prevent any medical condition. The efficacy and safety of supplements can vary, and ongoing research may impact current understanding. Always consult with a qualified healthcare provider for advice specific to your health needs, especially before making changes to medication or trying new supplements. The views expressed do not replace professional medical guidance. Summary The provided texts explore dihydroberberine (dhBBR), a derivative of the natural alkaloid berberine (BBR). Research highlights dhBBR's enhanced bioavailability and efficacy compared to BBR in treating type 2 diabetes and related conditions like obesity and insulin resistance in animal models and humans. Studies investigate dhBBR's mechanisms of action, including its effects on mitochondrial function and gut microbiota, and assess its safety profile. Further research also examines the pharmacokinetics and metabolism of both BBR and dhBBR, exploring various administration methods (oral, transdermal) and their impact on drug efficacy. Sources https://pubmed.ncbi.nlm.nih.gov/35010998/ https://pubmed.ncbi.nlm.nih.gov/35868606/ https://pubmed.ncbi.nlm.nih.gov/34386321/ https://pubmed.ncbi.nlm.nih.gov/34253428/ https://pubmed.ncbi.nlm.nih.gov/33623004/ https://pubmed.ncbi.nlm.nih.gov/31401380/ https://pubmed.ncbi.nlm.nih.gov/29579096/ https://pubmed.ncbi.nlm.nih.gov/38891813/ https://pubmed.ncbi.nlm.nih.gov/18285556/ https://pubmed.ncbi.nlm.nih.gov/21355331/ https://pubmed.ncbi.nlm.nih.gov/20663675/ https://pubmed.ncbi.nlm.nih.gov/26174047/ https://pubmed.ncbi.nlm.nih.gov/33493658/ https://pubmed.ncbi.nlm.nih.gov/36189746/ https://www.mdpi.com/1422-0067/25/11/5625 #Dihydroberberine #MicellarBerberine #Type2Diabetes #SupplementResearch #HealthSupplements #Berberine #InsulinResistance #Bioavailability #GutMicrobiota

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Weight loss is a topic that has been heavily discussed and debated for decades. With the rise of social media and the constant pressure to look a certain way, many people are constantly searching for quick and easy solutions to shed those extra pounds. One of the latest trends in the weight loss industry is the use of Shark Weight Loss Gummies. These gummies claim to help individuals lose weight quickly and effectively, but do they really work? In this article, we will take an in-depth look at Shark Weight Loss Gummies, their effectiveness, and whether or not they are worth the investment.

Shark Tank Episodes on Weight Loss Gummies

Shark Tank is a popular television show where entrepreneurs pitch their business ideas to a panel of investors in hopes of securing funding. Over the years, several weight loss products, including gummies, have been presented on the show. One episode in particular featured a company that created Shark Weight Loss Gummies, claiming that their product could help individuals lose weight without having to make any significant changes to their diet or exercise routine. The sharks were intrigued by the idea but had their doubts about the effectiveness of the product.

During the episode, the entrepreneurs behind Shark Weight Loss Gummies presented their product to the sharks, touting its natural ingredients and promising results. However, the sharks were skeptical and questioned the science behind the gummies. They also raised concerns about the lack of clinical studies to support the product’s claims. In the end, none of the sharks were willing to invest in the company, citing the lack of evidence to prove that the gummies actually worked.

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Despite the lack of support from the sharks, Shark Weight Loss Gummies gained popularity following their appearance on the show. Many viewers were intrigued by the idea of a quick and easy way to lose weight, and the company saw a significant increase in sales. However, questions still remain about the effectiveness of the gummies and whether or not they truly deliver on their promises.

Effectiveness of Shark Weight Loss Gummies

When it comes to weight loss products, it is essential to consider the ingredients and the science behind them. Shark Weight Loss Gummies claim to contain natural ingredients that can help individuals lose weight by suppressing their appetite and boosting their metabolism. These ingredients include green tea extract, garcinia cambogia, and apple cider vinegar, which are commonly used in weight loss supplements.

While these ingredients have been shown to have some weight loss benefits, their effectiveness in gummy form is questionable. The body may not absorb these ingredients as effectively when consumed in a gummy format, leading to reduced efficacy. Additionally, the dosages of these ingredients in the gummies may not be sufficient to produce significant weight loss results.

Furthermore, the lack of clinical studies to support the effectiveness of Shark Weight Loss Gummies is a significant red flag. Without scientific evidence to back up their claims, it is challenging to determine whether these gummies actually work. Many weight loss products make bold claims without any evidence to support them, leading to skepticism among consumers.

Are Shark Weight Loss Gummies Worth It?

Ultimately, the decision to try Shark Weight Loss Gummies comes down to personal preference and individual goals. While some people may see results from using these gummies, others may not experience any significant weight loss. It is essential to approach weight loss products with caution and skepticism, especially those that make bold claims without scientific evidence to support them.

If you are considering trying Shark Weight Loss Gummies, it is essential to consult with a healthcare provider or nutritionist before doing so. They can help you navigate the crowded weight loss market and choose products that are safe and effective. Remember, there is no magic pill for weight loss, and sustainable results require a combination of healthy eating, regular exercise, and lifestyle changes.

Before investing in Shark Weight Loss Gummies or any other weight loss product, do your research, read reviews, and approach with caution. Weight loss is a journey that requires time, dedication, and hard work, so be wary of products that promise quick fixes without any evidence to support their claims.

Conclusion

In conclusion, Shark Weight Loss Gummies may offer some benefits for individuals looking to lose weight, but their effectiveness remains questionable. Without scientific evidence to support their claims, it is challenging to determine whether these gummies actually work. It is essential to approach weight loss products with caution and skepticism, and to prioritize healthy eating, regular exercise, and lifestyle changes for long-term success. Remember, there is no magic pill for weight loss, and sustainable results require a holistic approach to health and wellness.