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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied.   We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss.   Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer

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For Personalized Diet Plans: Email - [email protected] -------------------- 🔗 Connect with Us on Social Media: 📌 Subscribe for more health & wellness tips: https://www.youtube.com/@FattoFabSuman 📸 Follow us on Instagram: https://www.instagram.com/suman_sunshine 🌐 Visit our blog for more: https://sumanpahuja.com/ 📘 Facebook: https://www.facebook.com/FattoFabSuman 🐦 Twitter/X: https://twitter.com/FattoFabSuman 💼 LinkedIn: https://www.linkedin.com/company/fat-to-fab/ -------------------- 👇 Don’t forget to like, comment, and subscribe for more natural health tips! #fattofab #weightlosstips #weightlosssecret Disclaimer: There is no guarantee of specific results and the results can vary from person to person. The content is only intended for informational purposes. Any information associated with my videos should not be considered as a substitute for prescriptions suggested by LOCAL beauty, diet, and health care professionals. If you like my video then do SUBSCRIBE to my channel. Please leave me a COMMENT and give THUMBS UP. It means a lot. Thank You. I wish you good health. SUMAN PAHUJA. ⚠️ This video is originally in [Hindi]. If you're hearing a dubbed voice, please go to settings - audio track - select "Original."

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To lose body fat effectively we all know it is about calories VS calories out. But it is essential to keep your protein high. At least 1 gram of protein for every 10 calories you consume.

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This is a 20 minute workout that is a high intensity cardio HIIT workout focused on fat burn and weight loss. We have 10 moves, 40 seconds work followed by 20 seconds rest. We will do 2 rounds of these 10 exercises. We are going to be using large muscles groups and jumping exercises to raise the heart rate to facilitate fat burning and weight loss. The exercise in the video will work most of the body including legs, glutes, shoulders, abs (belly) etc. The jumping version of the workout is advanced and NOT suitable to complete beginners. There are no-jumping modifications for each exercise that will get you a workout, but not raise the heart rate as much as the jumping exercises. If you're looking to lose weight and burn fat, especially belly fat, a combination of strength workouts, cardio workouts and diet is the most effective. At Home Workout Videos. Get Fit At Home! Website - https://www.bodyfittv.com/ Business Email - [email protected] Instagram - https://www.instagram.com/body_fit_tv/ Diet & Wellness Videos - https://www.youtube.com/c/TheDietChannel Warm Up Playlist: https://youtube.com/playlist?list=PLaGTYQUDoFydzpu2ZuQiMfXPThJIIw4N9 Cool Down Playlist: https://youtube.com/playlist?list=PLaGTYQUDoFydmZPXotSYvW7o8IQh5E-ov Some Other Workouts You Might Enjoy: 10 Minute Flat Belly Workout: https://youtu.be/vT9Lmpmc5ak 15 Minute Toned Legs Workout: https://youtu.be/4tUr3wHVAyM 10 Minute Upper Body Workout: https://youtu.be/Vs-863RpNbY 10 Minute Belly Burn Workout: https://youtu.be/Kzj_EQKdqic 15 Minute Cardio Workout: https://youtu.be/RShIdGxTxCs 30 Minute Full Body Toning Workout: https://youtu.be/wXEVLRFA8So 15 Minute Full Body Workout: https://youtu.be/A0ZMcG9mJj8 5 Minute Ab Workout: https://youtu.be/xrv6JmYlJH0 #fitness #workout #homeworkout #exercise #rheashroffekhlas #bodyfittv Disclaimer: Not all exercises are suitable for everyone and this or any other exercise program may result in injury. Please always consult your doctor before beginning this or any other exercise video or program. By performing any of the exercises in this exercise video or program, you assume all risks of injury from doing so. Body Fit TV, its associates and Rhea Shroff are not responsible or liable for any injury or loss you may sustain by participating in this exercise video or program. Always warm up before beginning any workout and never exercise beyond the level at which you feel comfortable. Make sure to prioritize your health and safety. The videos and programs is what works for me and my views and not meant to be advise to you. You can consult with a fitness and nutrition professional to help you figure out what works for you. Always prioritize your health and safety above all else.

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